Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis

Accessory and Central α-helices of Complexin Selectively Activate Ca2+ Triggering of Synaptic Exocytosis

Complexins, binding to assembling soluble NSF-attachment protein receptor (SNARE) complexes, activate Ca2+ triggered exocytosis and clamp spontaneous release in the presynaptic terminal. Functions of complexin are structural dependent and mechanistically distinct. To further understand the functiona...

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Bibliographic Details
Main Authors: Yi Yu, Su Chen, Xiaoqiang Mo, Jihong Gong, Chenhong Li, Xiaofei Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
complexin
Ca2+ triggered exocytosis
spontaneous release
SNARE protein
synaptic vesicle
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00061/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00061/full

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