The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients

The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients

BackgroundPIK3CA is a high-frequency mutation gene in colorectal cancer, while its prognostic value remains unclear. This study evaluated the mutation tendency, spectrum, prognosis power and predictive power in cetuximab treatment of PIK3CA in Chinese CRC cohort.MethodsThe PIK3CA exon 9 and 20 statu...

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Bibliographic Details
Main Authors: Xinhui Fu, Hanjie Lin, Xinjuan Fan, Yaxi Zhu, Chao Wang, Zhiting Chen, Xiaoli Tan, Jinglin Huang, Yacheng Cai, Yan Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
mutation spectrum
nomogram
PIK3CA
the predictive value
HRM test
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.595675/full

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