Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail†Approach

Comparative Studies of the Effects of Two Novel Sugar Drug Candidates on the CYP 1A2 and CYP 2E1 Enzymes in Different Sexed Rats Using a “Cocktail†Approach

The sex-based differences between the effects of two novel sugar-based drug candidates, a sulfated polymannuroguluronate (SPMG-911) and an acidic oligosaccharide sugar chain compound (AOSC-971), on the enzymes CYP 1A2 and CYP 2E1 were investigated. The results showed that neither SPMG-911 nor AOSC-9...

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Bibliographic Details
Main Authors: Chang-Xiao Liu, Mei-Yu Geng, Jie Shi
Format: Article
Language:English
Published: MDPI AG 2004-11-01
Series:Molecules
Subjects:
Cocktail approach
enzymes
drug safety evaluation.
Online Access:http://www.mdpi.com/1420-3049/9/11/978/

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