Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes.

Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes.

Brazilin is an active compound of Caesalpinia sappan L. (Leguminosae), which possesses pro-apoptotic and anti-inflammation potentials depending on the specific cell type. However, it is largely unknown whether autophagy is implicated in the mechanism underlying its chemotherapeutic and anti-inflamma...

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Main Authors: Hyunji Lee, Seong Wook Kang, Hee Sun Byun, Juhee Jeon, Kyeong Ah Park, Kidong Kang, Wonhyoung Seo, Minho Won, Jeong Ho Seok, Man-Deuk Han, Han-Ming Shen, Gang Min Hur
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4546660?pdf=render

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