Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix—A Comparative Analysis of Bioartificial Liver Microenvironments

Induced pluripotent stem cells (iPSCs) are new diagnostic and potentially therapeutic tools to model disease and assess the toxicity of pharmaceutical medications. A common limitation of cell lineages derived from iPSCs is a blunted phenotype compared with fully developed, endogenous cells. We exami...

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Bibliographic Details
Main Authors: Bo Wang, Adam E. Jakus, Pedro M. Baptista, Shay Soker, Alejandro Soto-Gutierrez, Michael M. Abecassis, Ramille N. Shah, Jason A. Wertheim
Format: Article
Language:English
Published: Wiley 2016-09-01
Series:Stem Cells Translational Medicine
Subjects:
Online Access:https://doi.org/10.5966/sctm.2015-0235