Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus

Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus

The gut microbiota, as an important factor affecting host health, plays a significant role in the occurrence and development of diabetes mellitus (DM), and the mechanism may be related to excessive endotoxins, altered short-chain fatty acids (SCFAs), and disordered bile acid metabolism. Traditional...

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Main Authors: Boxun Zhang, Rensong Yue, Yuan Chen, Maoyi Yang, Xiaoying Huang, Jiacheng Shui, Yuliang Peng, Jiawei Chin
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Evidence-Based Complementary and Alternative Medicine
Online Access:http://dx.doi.org/10.1155/2019/2634898
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spelling doaj-66fcf5c76fb4442e870bcc14e47c96b02020-11-25T01:01:45ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882019-01-01201910.1155/2019/26348982634898Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes MellitusBoxun Zhang0Rensong Yue1Yuan Chen2Maoyi Yang3Xiaoying Huang4Jiacheng Shui5Yuliang Peng6Jiawei Chin7Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, ChinaThe gut microbiota, as an important factor affecting host health, plays a significant role in the occurrence and development of diabetes mellitus (DM), and the mechanism may be related to excessive endotoxins, altered short-chain fatty acids (SCFAs), and disordered bile acid metabolism. Traditional Chinese medicine (TCM) has a long history of treating DM, but its mechanism is not very clear. Recent research has suggested that Chinese herbal medicine can improve glucose metabolism by remodeling the gut microbiota, which opens new avenues for further research on hypoglycemic mechanisms. This review presents the recent progress of Chinese herbs, herbal extracts, and herbal compound preparations in treating DM through regulating the gut microbiota and summarizes the main mechanisms involved, namely, anti-inflammatory and antioxidative effects, protecting the intestinal barrier and inhibiting lipotoxicity. In addition, some suggestions for improvement are also proposed.http://dx.doi.org/10.1155/2019/2634898
collection DOAJ
language English
format Article
sources DOAJ
author Boxun Zhang
Rensong Yue
Yuan Chen
Maoyi Yang
Xiaoying Huang
Jiacheng Shui
Yuliang Peng
Jiawei Chin
spellingShingle Boxun Zhang
Rensong Yue
Yuan Chen
Maoyi Yang
Xiaoying Huang
Jiacheng Shui
Yuliang Peng
Jiawei Chin
Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus
Evidence-Based Complementary and Alternative Medicine
author_facet Boxun Zhang
Rensong Yue
Yuan Chen
Maoyi Yang
Xiaoying Huang
Jiacheng Shui
Yuliang Peng
Jiawei Chin
author_sort Boxun Zhang
title Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus
title_short Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus
title_full Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus
title_fullStr Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus
title_full_unstemmed Gut Microbiota, a Potential New Target for Chinese Herbal Medicines in Treating Diabetes Mellitus
title_sort gut microbiota, a potential new target for chinese herbal medicines in treating diabetes mellitus
publisher Hindawi Limited
series Evidence-Based Complementary and Alternative Medicine
issn 1741-427X
1741-4288
publishDate 2019-01-01
description The gut microbiota, as an important factor affecting host health, plays a significant role in the occurrence and development of diabetes mellitus (DM), and the mechanism may be related to excessive endotoxins, altered short-chain fatty acids (SCFAs), and disordered bile acid metabolism. Traditional Chinese medicine (TCM) has a long history of treating DM, but its mechanism is not very clear. Recent research has suggested that Chinese herbal medicine can improve glucose metabolism by remodeling the gut microbiota, which opens new avenues for further research on hypoglycemic mechanisms. This review presents the recent progress of Chinese herbs, herbal extracts, and herbal compound preparations in treating DM through regulating the gut microbiota and summarizes the main mechanisms involved, namely, anti-inflammatory and antioxidative effects, protecting the intestinal barrier and inhibiting lipotoxicity. In addition, some suggestions for improvement are also proposed.
url http://dx.doi.org/10.1155/2019/2634898
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