Consistency of the S5 DNA methylation classifier in formalin‐fixed biopsies versus corresponding exfoliated cells for the detection of pre‐cancerous cervical lesions

Consistency of the S5 DNA methylation classifier in formalin‐fixed biopsies versus corresponding exfoliated cells for the detection of pre‐cancerous cervical lesions

Abstract Methylation biomarkers are promising tools for diagnosis and disease prevention. The S5 classifier is aimed at the prevention of cervical cancer by the early detection of cervical intraepithelial neoplasia (CIN). S5 is based on pyrosequencing a promoter region of EPB41L3 and five late regio...

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Bibliographic Details
Main Authors: Caroline Reuter, Matthew Preece, Rawinder Banwait, Sabrina Boer, Jack Cuzick, Attila Lorincz, Belinda Nedjai
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Cancer Medicine
Subjects:
biomarker
cervical cancer
DNA methylation
formalin‐fixed paraffin‐embedded samples (FFPE)
S5 classifier
Online Access:https://doi.org/10.1002/cam4.3849

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