CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation.

CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation.

Microglial activation, characterized by p38 MAPK or p44/42 MAPK pathway signal transduction, occurs in Alzheimer's disease (AD). Our previous studies demonstrated CD45, a membrane-bound protein tyrosine phosphatase (PTP), opposed beta-amyloid (Abeta) peptide-induced microglial activation via in...

Full description

Bibliographic Details
Main Authors:	Yuyan Zhu, Huayan Hou, William V Nikolic, Jared Ehrhart, Elona Rrapo, Paula Bickford, Brian Giunta, Jun Tan
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-05-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC2366070?pdf=render

Similar Items

Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
by: Bickford Paula, et al.
Published: (2008-09-01)

Flipping the switches: CD40 and CD45 modulation of microglial activation states in HIV associated dementia (HAD)
by: Jin Jingji, et al.
Published: (2011-01-01)

Sequestration of the Abeta peptide prevents toxicity and promotes degradation in vivo.
by: Leila M Luheshi, et al.
Published: (2010-03-01)

Specific Binding of Alzheimer’s Abeta Peptide Fibrils to Single Walled Carbon Nanotubes
by: Steingrimur Stefansson, et al.
Published: (2012-10-01)

Is Abeta a sufficient Biomarker for monitoring anti-Abeta clinical studies? A critical review.
by: Jens eMoreth, et al.
Published: (2013-07-01)

CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence
by: Scott M. Krummey, et al.
Published: (2020-02-01)

Stimulation of cannabinoid receptor 2 (CB<sub>2</sub>) suppresses microglial activation
by: Fernandez Francisco, et al.
Published: (2005-12-01)

B-Cell Depletion Improves Islet Allograft Survival with Anti-CD45RB
by: Kang Mi Lee, et al.
Published: (2014-02-01)

Optimization of anti-Abeta antibody therapy
by: Karlnoski, Rachel Anne
Published: (2007)

Highly specific and ultrasensitive plasma test detects Abeta(1–42) and Abeta(1–40) in Alzheimer’s disease
by: Elisabeth H. Thijssen, et al.
Published: (2021-05-01)

p38 MAPK, microglial signaling, and neuropathic pain
by: Suter Marc R, et al.
Published: (2007-11-01)

Inflammaging as a prodrome to Alzheimer's disease
by: Rrapo Elona, et al.
Published: (2008-11-01)

Trimethyltin-Induced Microglial Activation via NADPH Oxidase and MAPKs Pathway in BV-2 Microglial Cells
by: Da Jung Kim, et al.
Published: (2015-01-01)

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.
by: Tao Yang, et al.
Published: (2008-01-01)

Effects of Different Force Fields and Temperatures on the Structural Character of Abeta (12–28) Peptide in Aqueous Solution
by: Jihua Wang, et al.
Published: (2011-11-01)

Mechanism of Early Stage Abeta Amyloid Formation
by: Li, Lei
Published: (2008)

Study of the Pathophysiological Properties of Abeta Aggregates and the Protective Mechanisms of EGb761 against the Cytotoxicity of Abeta Aggregates on PC12 Cells
by: Chang Pei-Teh, et al.
Published: (2002)

How cholesterol constrains glycolipid conformation for optimal recognition of Alzheimer's beta amyloid peptide (Abeta1-40).
by: Nouara Yahi, et al.
Published: (2010-01-01)

Effects of Monoclonal Anti-Abeta Antibodies on the Amyloid Beta Peptide Fibrillogenesis and their Involvement in the Clearance of Alzheimer's Disease Plaques
by: Jimenez, Jeffy Pilar
Published: (2010)

The effect of high glucose on APP metabolism and Abeta production
by: Yang, Yi
Published: (2013)

The effect of high glucose on APP metabolism and Abeta production
by: Yang, Yi
Published: (2013)

The effect of high glucose on APP metabolism and Abeta production
by: Yang, Yi
Published: (2013)

Mannan-Abeta<sub>28 </sub>conjugate prevents Abeta-plaque deposition, but increases microhemorrhages in the brains of vaccinated Tg2576 (APPsw) mice
by: Karapetyan Adrine, et al.
Published: (2008-09-01)

The Effects of Retinoic Acid and Anti-CD45RB on Regulatory T Cell Generation as a Means to Achieve Allograft Prolongation
by: Eliades, Philip
Published: (2011)

Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.
by: Ian Catchpole, et al.
Published: (2013-01-01)

Activation of PERK signaling attenuates Abeta-mediated ER stress.
by: Do Yeon Lee, et al.
Published: (2010-05-01)

Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
by: Boche, D., et al.
Published: (2008)

Effect of active Abeta immunotherapy on neurons in human Alzheimer's disease
by: Paquet, Claire, et al.
Published: (2015)

Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide
by: Danny Alon, et al.
Published: (2021-08-01)

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders
by: Giunta Brian, et al.
Published: (2011-06-01)

T cell-intrinsic TLR2 stimulation promotes IL-10 expression and suppressive activity by CD45RbHi T cells.
by: Janice C Jun, et al.
Published: (2017-01-01)

The effects of beta-amyloid peptide on microglial function
by: Milton, R. H.
Published: (2010)

Bifunctional Modulators of Abeta Aggregation as Potential Agents for Alzheimer's Disease Therapy
by: Li-Hsin Hsu, et al.
Published: (2013)

A chemical analog of curcumin as an improved inhibitor of amyloid Abeta oligomerization.
by: Robert A Orlando, et al.
Published: (2012-01-01)

Abeta mediated diminution of MTT reduction--an artefact of single cell culture?
by: Raik Rönicke, et al.
Published: (2008-09-01)

A Study of the Process and Causes of Abeta(25-35) Amyloid Formation
by: Ridinger, Katherine V.
Published: (2011)

Acute Blast Injury Reduces Brain Abeta in Two Rodent Species
by: Rita eDe Gasperi, et al.
Published: (2012-12-01)

The action mechanisms of human platelet aggregation induced by Abeta25-35
by: Hsiao-Ting Chou, et al.
Published: (2008)

Molecular structures of quiescently grown and brain-derived polymorphic fibrils of the Alzheimer amyloid abeta9-40 peptide: a comparison to agitated fibrils.
by: Chun Wu, et al.
Published: (2010-03-01)

Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68
by: Yaung, Stephanie J., et al.
Published: (2015)