Engraftment of neural stem cells in the treatment of spinal cord injury

Engraftment of neural stem cells in the treatment of spinal cord injury

Spinal cord injury is one of the main causes of disability in the young population. Based on the underlying pathological changes, many modalities of treatments have been trialed. However, the most promising so far, has been the replacement of lost cellular elements, using stem cells and non-stem cel...

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Main Authors: Martin M. Mortazavi, Mohammad Jaber, Nimer Adeeb, Aman Deep, Nicole Hose, Mona Rezaei, Salman Abbasi Fard, Babak Kateb, Parham Yashar, Mark A. Liker, R. Shane Tubbs
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Translational Research in Anatomy
Online Access:http://www.sciencedirect.com/science/article/pii/S2214854X15300042
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spelling doaj-66e9cedf7f2e4eeba56e40ea3a318c4f2020-11-24T23:44:53ZengElsevierTranslational Research in Anatomy2214-854X2015-12-0111116Engraftment of neural stem cells in the treatment of spinal cord injuryMartin M. Mortazavi0Mohammad Jaber1Nimer Adeeb2Aman Deep3Nicole Hose4Mona Rezaei5Salman Abbasi Fard6Babak Kateb7Parham Yashar8Mark A. Liker9R. Shane Tubbs10California Neurosurgical Institute, Thousand Oaks, CA, USA; Corresponding author. California Neurosurgical Institute, 77 Rolling Oaks Drive, Suite 203, Thousand Oaks, CA 91361, USA.California Neurosurgical Institute, Thousand Oaks, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USA; Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USA; Society of Brain Mapping and Therapeutics, Santa Monica, CA, USACalifornia Neurosurgical Institute, Thousand Oaks, CA, USADepartment of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USASeattle Science Foundation, Seattle, WA, USASpinal cord injury is one of the main causes of disability in the young population. Based on the underlying pathological changes, many modalities of treatments have been trialed. However, the most promising so far, has been the replacement of lost cellular elements, using stem cells and non-stem cells transplantation. The route of cellular administration and engraftment into the site of injury is an important determining factor for functional outcome, and should be chosen to be safe and efficacious in human patients. Herein, we will review the underlying changes following spinal cord injury, and the possible routes of cellular transplantation. Keywords: Stem cell therapy, Engraftment, Intramedullary, Intrathecal, Intravascular, Intraventricularhttp://www.sciencedirect.com/science/article/pii/S2214854X15300042
collection DOAJ
language English
format Article
sources DOAJ
author Martin M. Mortazavi
Mohammad Jaber
Nimer Adeeb
Aman Deep
Nicole Hose
Mona Rezaei
Salman Abbasi Fard
Babak Kateb
Parham Yashar
Mark A. Liker
R. Shane Tubbs
spellingShingle Martin M. Mortazavi
Mohammad Jaber
Nimer Adeeb
Aman Deep
Nicole Hose
Mona Rezaei
Salman Abbasi Fard
Babak Kateb
Parham Yashar
Mark A. Liker
R. Shane Tubbs
Engraftment of neural stem cells in the treatment of spinal cord injury
Translational Research in Anatomy
author_facet Martin M. Mortazavi
Mohammad Jaber
Nimer Adeeb
Aman Deep
Nicole Hose
Mona Rezaei
Salman Abbasi Fard
Babak Kateb
Parham Yashar
Mark A. Liker
R. Shane Tubbs
author_sort Martin M. Mortazavi
title Engraftment of neural stem cells in the treatment of spinal cord injury
title_short Engraftment of neural stem cells in the treatment of spinal cord injury
title_full Engraftment of neural stem cells in the treatment of spinal cord injury
title_fullStr Engraftment of neural stem cells in the treatment of spinal cord injury
title_full_unstemmed Engraftment of neural stem cells in the treatment of spinal cord injury
title_sort engraftment of neural stem cells in the treatment of spinal cord injury
publisher Elsevier
series Translational Research in Anatomy
issn 2214-854X
publishDate 2015-12-01
description Spinal cord injury is one of the main causes of disability in the young population. Based on the underlying pathological changes, many modalities of treatments have been trialed. However, the most promising so far, has been the replacement of lost cellular elements, using stem cells and non-stem cells transplantation. The route of cellular administration and engraftment into the site of injury is an important determining factor for functional outcome, and should be chosen to be safe and efficacious in human patients. Herein, we will review the underlying changes following spinal cord injury, and the possible routes of cellular transplantation. Keywords: Stem cell therapy, Engraftment, Intramedullary, Intrathecal, Intravascular, Intraventricular
url http://www.sciencedirect.com/science/article/pii/S2214854X15300042
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