Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation

Catalpol was tested for various disorders including diabetes mellitus. Numerous molecular mechanisms have emerged supporting its biological effects but with little information towards its insulin sensitizing effect. In this study, we have investigated its effect on skeletal muscle mitochondrial resp...

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Bibliographic Details
Main Authors: Kah Heng Yap, Gan Sook Yee, Mayuren Candasamy, Swee Ching Tan, Shadab Md, Abu Bakar Abdul Majeed, Subrat Kumar Bhattamisra
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
catalpol
type-2 diabetes mellitus
insulin sensitivity
glucose homeostasis
oxygen consumption rate
mitochondrial respiration
Online Access:https://www.mdpi.com/2218-273X/10/10/1360

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