Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication

Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication

Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential t...

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Main Authors: Indong Jun, Hyung-Seop Han, James R. Edwards, Hojeong Jeon
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:International Journal of Molecular Sciences
Subjects:
electrospinning
nanofiber scaffolds
tissue engineering
extracellular matrix-mimicking geometries
Online Access:http://www.mdpi.com/1422-0067/19/3/745
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spelling doaj-66d94e1155f547a686cee8cb78aaf6292020-11-25T01:08:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-03-0119374510.3390/ijms19030745ijms19030745Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and FabricationIndong Jun0Hyung-Seop Han1James R. Edwards2Hojeong Jeon3Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford OX3 7LD, UKBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford OX3 7LD, UKBotnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford OX3 7LD, UKCenter for Biomaterials, Korea Institute of Science & Technology (KIST), Seoul 02792, KoreaElectrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate the formation of artificial functional tissues. In this review, we summarize the fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues. Moreover, several approaches for the formation of three-dimensional fibrous scaffolds arranged in hierarchical structures for tissue engineering are also presented.http://www.mdpi.com/1422-0067/19/3/745electrospinningnanofiber scaffoldstissue engineeringextracellular matrix-mimicking geometries
collection DOAJ
language English
format Article
sources DOAJ
author Indong Jun
Hyung-Seop Han
James R. Edwards
Hojeong Jeon
spellingShingle Indong Jun
Hyung-Seop Han
James R. Edwards
Hojeong Jeon
Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication
International Journal of Molecular Sciences
electrospinning
nanofiber scaffolds
tissue engineering
extracellular matrix-mimicking geometries
author_facet Indong Jun
Hyung-Seop Han
James R. Edwards
Hojeong Jeon
author_sort Indong Jun
title Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication
title_short Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication
title_full Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication
title_fullStr Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication
title_full_unstemmed Electrospun Fibrous Scaffolds for Tissue Engineering: Viewpoints on Architecture and Fabrication
title_sort electrospun fibrous scaffolds for tissue engineering: viewpoints on architecture and fabrication
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2018-03-01
description Electrospinning has been used for the fabrication of extracellular matrix (ECM)-mimicking fibrous scaffolds for several decades. Electrospun fibrous scaffolds provide nanoscale/microscale fibrous structures with interconnecting pores, resembling natural ECM in tissues, and showing a high potential to facilitate the formation of artificial functional tissues. In this review, we summarize the fundamental principles of electrospinning processes for generating complex fibrous scaffold geometries that are similar in structural complexity to the ECM of living tissues. Moreover, several approaches for the formation of three-dimensional fibrous scaffolds arranged in hierarchical structures for tissue engineering are also presented.
topic electrospinning
nanofiber scaffolds
tissue engineering
extracellular matrix-mimicking geometries
url http://www.mdpi.com/1422-0067/19/3/745
work_keys_str_mv AT indongjun electrospunfibrousscaffoldsfortissueengineeringviewpointsonarchitectureandfabrication
AT hyungseophan electrospunfibrousscaffoldsfortissueengineeringviewpointsonarchitectureandfabrication
AT jamesredwards electrospunfibrousscaffoldsfortissueengineeringviewpointsonarchitectureandfabrication
AT hojeongjeon electrospunfibrousscaffoldsfortissueengineeringviewpointsonarchitectureandfabrication
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