P-glycoprotein and Its Role in Treatment Resistance

• Main Authors: Isil Gogcegoz Gul, Gul Eryilmaz, K. Oguz Karamustafalioglu
• Format: Article
• Language: English
• Published: Psikiyatride Güncel Yaklaşımlar 2016-03-01
• Series: Psikiyatride Guncel Yaklasimlar
• Subjects: P glycoprotein; multipl drug resistance; blood and ndash;brain barrier
• Online Access: http://www.cappsy.org/archives/vol8/no1/cap_08_01_02.pdf

Polypharmacy which has often used to increase efficacy of treatment and to prevent resistance in psychiatry may lead to pharmacokinetic and pharmacodynamic drug interactions. One of the inten-sively studied topic in recent years to clarify the mechanism of drug interactions, in the pharmacoki-netic area is p-glycoprotein related drug-drug and drug-food interactions. The interactions of some drugs with p-glycoprotein which is a carrier protein, can lead to a decrease in the bioavailability of these drugs and reduction in passage through the blood-brain barrier. In this review, the role of p-glycoprotein on drug pharmacokinetics and bioavailability of psychiatric drugs are discussed. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(1): 19-31]