Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension
Nebulization delivery of adeno-associated virus serotype 1 encoding sarcoplasmic reticulum Ca 2+ -ATPase2a (AAV1.SERCA2a) gene was examined in a Yukatan miniature swine model of chronic pulmonary hypertension (n = 13). Nebulization of AAV1.SERCA2a resulted in homogenous distribution of vectors, lowe...
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Bibliographic Details
| Main Authors: |
Shin Watanabe,
Kiyotake Ishikawa,
Maria Plataki,
Olympia Bikou,
Erik Kohlbrenner,
Jaume Aguero,
Lahouaria Hadri,
Iratxe Zarragoikoetxea,
Kenneth Fish,
Jane A. Leopold,
Roger J. Hajjar |
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| Format: | Article
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| Language: | English |
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| Published: |
SAGE Publishing
2018-09-01
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| Series: | Pulmonary Circulation
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| Online Access: | https://doi.org/10.1177/2045894018799738
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