OUR EXPERIENCES IN TREATMENT OF ENDOMETRITIS USING LOTAGEN® IN DIARY COWS

• Main Authors: Amel Ćutuk, Nasir Sinanović, Benjamin Čengić, Tarik Mutevelić, Hidajet Pajić, Nazif Varatanović
• Format: Article
• Language: Bosnian
• Published: Veterinary Faculty Sarajevo 2012-07-01
• Series: Veterinaria
• Online Access: https://veterinaria-sarajevo.com/ojs/index.php/vet/article/view/10
• ISSN: 0372-6827; 2233-1360

<span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"> Goal of this research was to explore the efficiency of intrauterine application of 4% solution of Lotagen^® in the treatment of chronic endometritis of different severity, and to examine the effects of therapy to the breeding-reproductive parameters in animals treated under the real field conditions.</span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span>Research was conducted between May 2005 - March 2007 by analyzing the data from the protocol of artifitial insemination and treatment of sterility<span style="mso-spacerun: yes;"> </span>in the county of Sanski Most. </span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span>Research included dairy cows from 95 stables when chronic endometritis was diagnosed by clinical examination (n=126) at the earliest 21 day postpartum.<span style="mso-spacerun: yes;"> </span>Animals were treated intrauterinelly with 100 to 180 ml (primiparous and multiparous) of 4% solution of<span style="mso-spacerun: yes;"> </span>Lotagen^® during puerperium or in estrus, after puerperium.</span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><strong style="mso-bidi-font-weight: normal;"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span></span></strong><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;">Out of total of 126 dairy cows with chronic endometritis treated with Lotagen^®<span style="mso-spacerun: yes;"> </span>once or more times, including a group of non-treated animals, clinical healing was noted in 117 animals (92,8%), artificial insemination was performed in 115 (87,3%) and 95 animals had conception (86,3%).<span style="mso-spacerun: yes;"> </span>Due to the lack of clinical healing, fertility loss or some other reasons, 31 cows were excluded (24,6%) from breeding and this research.<span style="mso-spacerun: yes;"> </span></span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><strong style="mso-bidi-font-weight: normal;"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span></span></strong><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;">The treatment<strong style="mso-bidi-font-weight: normal;"> </strong>results as well as some fertility parameters were affected by severity of chronic endometritis and time of therapy introduction. The more time elapsed from parturition, the severity of endometritis decreased. Consequently, the percentage of cured animals after the first treatment increased from 59,5% to 79,6% (P &lt; 0,05). </span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span>Percentage of healing in E 1-2 (<em style="mso-bidi-font-style: normal;">endometritis catarrhalis et mucopurulenta</em>) was 68,2% after the first treatment and was significant in relation to 44,4% in E 3-4 (<em style="mso-bidi-font-style: normal;">endometritis purulenta et pyometra</em>).</span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><strong style="mso-bidi-font-weight: normal;"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span></span></strong><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;">Taking into consideration the conception accomplished in two examined groups, obvious differences are shown: experimental group - 91,5%, control group - 76,9% (P&lt;0,05).<span style="mso-spacerun: yes;"> </span>The effects of treatment to the breeding-reproductive parameters were also evalauted with high conception rates noticed in treated animals.</span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"> </span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; text-align: justify; text-justify: inter-ideograph;" class="MsoNormal"><span lang="BS-LATN-BA" style="line-height: 110%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;; font-size: 10pt; mso-ansi-language: BS-LATN-BA;"><span style="mso-tab-count: 1;"> </span>Key words: chronic endometritis, dairy cows, Lotagen^®</span></p><span style="font-family: Times New Roman; font-size: small;"> </span>