EFFECT OF A SYNTHESIS PRODUCT (BY-PRODUCT OF SALICYLIC ACID) IN COMPARISON WITH BASIS STRUCTURAL COMPOUNDS ON SOME PROTEIC METABOLISM PARAMETERS IN RATS

• Main Authors: LETIłIA STANA, ALEXANDRA TRIF, LOREDANA GABRIELA STANA, ALFA XENIA LUPEA, MIRABELA PĂDURE, F. MUSELIN
• Format: Article
• Language: English
• Published: Agroprint Timisoara 2008-05-01
• Series: Scientific Papers Animal Science and Biotechnologies
• Subjects: protein; albumin; urea; creatinine; rat
• Online Access: http://spasb.ro/index.php/spasb/article/view/1291

The aim of the study was to relieve the effect of synthesis product (by-product of salicylic acid) administration 5-cloro-2hidroxy-azotil-sulfamoil-fenil benzamide (5ClSA-SA) in comparison with basic structural compounds (salicylamide and sulfanilamide) on some parameters of proteic metabolism on rats. The synthesis product 5ClSA-SA is amide of 5 chlorosalycilic acid with sulfanilamide synthesized at The Technical University, Faculty of Industrial Chemistry of Timisoara. The experimental results demonstrate that the synthesis product has determinate a strong significant increase (p<0.01) of proteinemia compared to test, over the physiological limits; salicylamide has induces the significant increase (p<0.05), and sulfanilamide has induced the significant decrease (p<0.05) of total proteins compared to test but in physiological limits. After the administration of the three substances, the albumin and urea values has strong significant decrease (p<0.01) compared to test and under the physiological limits. The synthesis product has not determinate significant differences (p>0.05) of creatinine compared to test, obtained values being situated in physiological limits, while salicylamide and sulfanilamide have induced strong significant decrease (p>0.01), respectively significant (p>0.05) compared to test and under physiological limits.