Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities.

The cytosolic chaperone network of Saccharomyces cerevisiae is intimately associated with the emergence and maintenance of prion traits. Recently, the Hsp110 protein, Sse1, has been identified as a nucleotide exchange factor (NEF) for both cytosolic Hsp70 chaperone family members, Ssa1 and Ssb1. We...

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Bibliographic Details
Main Authors: Heather Sadlish, Heike Rampelt, James Shorter, Renee D Wegrzyn, Claes Andréasson, Susan Lindquist, Bernd Bukau
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2258148?pdf=render