Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity

Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity

Drug-induced liver toxicity is one of the most common reasons for the failure of drugs in clinical trials and frequent withdrawal from the market. Reasons for such failures include the low predictive power of in vivo studies, that is mainly caused by metabolic differences between humans and animals,...

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Bibliographic Details
Main Authors: Marc Ruoß, Silas Rebholz, Marina Weimer, Carl Grom-Baumgarten, Kiriaki Athanasopulu, Ralf Kemkemer, Hanno Käß, Sabrina Ehnert, Andreas K. Nussler
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Journal of Functional Biomaterials
Subjects:
scaffold culture
stiffness
in vitro model
pre-coating
arg-gly-asp (rgd)-peptides
cell attachment
Online Access:https://www.mdpi.com/2079-4983/11/1/17

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