Clinical application of procalcitonin combined with interleukin-6 in the diagnosis of systemic inflammatory response syndrome

• Main Authors: Ying Zhai, Li Ma, Xin-Xin Xiu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-10-01
• Series: Journal of Hainan Medical University
• Subjects: Systemic inflammatory response syndrome; Procalcitonin; Interleukin-6; Systemic inflammatory response syndrome(SIRS)
• Online Access: http://www.hnykdxxb.com/PDF/201820/06.pdf

Objective: To investigate the clinical application value of procalcitonin(PCT) combined with interleukin-6(IL-6) in the diagnosis of systemic inflammatory response syndrome(SIRS). Methods: 115 cases of SIRS patients were divided into sepsis group(n＝46) and non-infectious SIRS group(n＝69). The serum levels of PCT, IL-6 were detected within 24 h of admission in two groups. White blood cell count (WBC), neutrophil counts (N), neutrophil percentage (N %), C - reactive protein (CRP) and acute physiology and chronic health evaluation (APACHE Ⅱ score), sequential organ failure score (SOFA score) were recorded. Results: APACHE Ⅱ score, SOFA score, hospital mortality had statistical differences between sepsis group and noninfectious SIRS group (P < 0.05). The serum levels of CRP、 PCT、 IL-6 and N% in sepsis group were higher than those in noninfectious SIRS group(P<0.05). PCT and IL - 6 were positively correlated with APACHE Ⅱ scores (r = 0.580, 0.463), N, N %, PCT, IL - 6 were positively correlated with SOFA scores (r = 0.371, 0.393, 0.371, 0.393), PCT was positively related with hospital mortality (r = 0.349). ROC curve analysis showed that compared with CRP, N, N% and other inflammatory markers, the AUC of PCT, il-6 and infection score was larger, and the value of diagnosis was higher. Conclusion: The combined detection of PCT and IL-6 is more effective than single detection in prognosis of sepsis.