Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling

Synthetic biological pattern formation is challenging to engineer due to theoretical complexity and practical limitations. Here, the authors introduce a cell-in-the-loop approach in which cells interact through in silico signaling.

Bibliographic Details
Main Authors:	Melinda Liu Perkins, Dirk Benzinger, Murat Arcak, Mustafa Khammash
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15166-3

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spelling	doaj-66a0e8a410b8447d89243a33e77da9542021-05-11T09:04:58ZengNature Publishing GroupNature Communications2041-17232020-03-0111111010.1038/s41467-020-15166-3Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signalingMelinda Liu Perkins0Dirk Benzinger1Murat Arcak2Mustafa Khammash3Department of Electrical Engineering, University of CaliforniaDepartment of Biosystems Science and Engineering, ETH ZürichDepartment of Electrical Engineering, University of CaliforniaDepartment of Biosystems Science and Engineering, ETH ZürichSynthetic biological pattern formation is challenging to engineer due to theoretical complexity and practical limitations. Here, the authors introduce a cell-in-the-loop approach in which cells interact through in silico signaling.https://doi.org/10.1038/s41467-020-15166-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Melinda Liu Perkins Dirk Benzinger Murat Arcak Mustafa Khammash
spellingShingle	Melinda Liu Perkins Dirk Benzinger Murat Arcak Mustafa Khammash Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling Nature Communications
author_facet	Melinda Liu Perkins Dirk Benzinger Murat Arcak Mustafa Khammash
author_sort	Melinda Liu Perkins
title	Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
title_short	Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
title_full	Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
title_fullStr	Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
title_full_unstemmed	Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
title_sort	cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-03-01
description	Synthetic biological pattern formation is challenging to engineer due to theoretical complexity and practical limitations. Here, the authors introduce a cell-in-the-loop approach in which cells interact through in silico signaling.
url	https://doi.org/10.1038/s41467-020-15166-3
work_keys_str_mv	AT melindaliuperkins cellinthelooppatternformationwithoptogeneticallyemulatedcelltocellsignaling AT dirkbenzinger cellinthelooppatternformationwithoptogeneticallyemulatedcelltocellsignaling AT muratarcak cellinthelooppatternformationwithoptogeneticallyemulatedcelltocellsignaling AT mustafakhammash cellinthelooppatternformationwithoptogeneticallyemulatedcelltocellsignaling
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Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling

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