Rapamycin is Effective for Upper but not for Lower Gastrointestinal Crohn’s Disease-Related Stricture: A Pilot Study

Rapamycin is Effective for Upper but not for Lower Gastrointestinal Crohn’s Disease-Related Stricture: A Pilot Study

Crohn’s disease (CD)-related fibrotic stricture remains a clinical challenge because of no effective treatments. This study aimed to evaluate the potential efficacy of rapamycin in patients with CD-related strictures in different locations in gastrointestinal tract. A pilot prospective study on usin...

Full description

Bibliographic Details
Main Authors:	Min Zhong, Bota Cui, Jie Xiang, Xia Wu, Quan Wen, Qianqian Li, Faming Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-02-01
Series:	Frontiers in Pharmacology
Subjects:	Crohn’s disease rapamycin fibrosis stricture inflammatory bowel diseases duodenum obstruction
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2020.617535/full

Similar Items

Endoscopic management of strictures in patients with Crohn's disease - A multi-center experience in Taiwan
by: Chen-Wang Chang, et al.
Published: (2020-10-01)

Fibrostenotic strictures in Crohn’s disease
by: Jun Hwan Yoo, et al.
Published: (2020-10-01)

The bowel preparation for magnetic resonance enterography in patients with Crohn’s disease: study protocol for a randomized controlled trial
by: Min Dai, et al.
Published: (2019-01-01)

Endoscopic Balloon Dilation for Crohn’s Disease-Associated Strictures
by: Thomas Klag, et al.
Published: (2017-09-01)

Editorial: Factors Promoting Development of Fibrosis in Crohn’s Disease
by: Jennifer Bailey
Published: (2017-09-01)

Current status of endoscopic balloon dilation for Crohn's disease
by: Fumihito Hirai
Published: (2017-04-01)

Refractory Duodenal Crohn's Disease Successfully Treated with Infliximab
by: You Lim Kim, et al.
Published: (2014-01-01)

Fecal Microbiota Transplantation is a Promising Switch Therapy for Patients with Prior Failure of Infliximab in Crohn’s Disease
by: Qianqian Li, et al.
Published: (2021-05-01)

Prognostic factors, effectiveness and safety of endoscopic balloon dilatation for de novo and anastomotic strictures in Crohn’s disease—A multicenter “real life” study
by: Anita Bálint, et al.
Published: (2016-12-01)

High grade anorectal stricture complicating Crohn's disease: endoscopic treatment using insulated-tip knife
by: Hyung Ku Chon, et al.
Published: (2016-07-01)

A Food Impaction in Crohn’s Ileal Stricture
by: Hokama, Akira, et al.
Published: (2010-02-01)

Risk of surgery in patients with stricturing type of Crohn’s disease at the initial diagnosis: a single center experience
by: Yuji Maehata, et al.
Published: (2019-07-01)

Plastias de estenoses jejunais, ileais e ileocecais na doença de Crohn : analise de resultados imediatos e tardios
by: Ayrizono, Maria de Lourdes Setsuko, 1962-
Published: (2005)

Computed tomography and magnetic resonance imaging in the diagnosis of the small and large intestine strictures in Crohn’s disease. Radiological semiotics and assessment of the inflammation activity
by: S. E. Dubrova, et al.
Published: (2018-12-01)

Predictive factors for malignancy in undiagnosed isolated small bowel strictures
by: Ujjwal Sonika, et al.
Published: (2017-10-01)

Crohn’s Strictures—Moving Away from the Knife
by: Emily Stenke, et al.
Published: (2017-06-01)

Optimal use of biologics with endoscopic balloon dilatation for repeated intestinal strictures in Crohn's disease
by: Akihito Uda, et al.
Published: (2020-06-01)

Genetic influences on the development of fibrosis in Crohn’s Disease
by: Bram eVerstockt, et al.
Published: (2016-05-01)

Gastrointestinal Tuberculosis Mimicking Crohn’s Disease
by: Maria Ana Rafael, et al.
Published: (2019-12-01)

Ultrasonographic Evaluation of Intestinal Fibrosis and Inflammation in Crohn’s Disease. The State of the Art
by: Francesca Ferretti, et al.
Published: (2021-04-01)

Intestinal Stricture in Crohn's Disease
by: Chen-Wang Chang, et al.
Published: (2015-01-01)

The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
by: Renata Curciarello, et al.
Published: (2017-08-01)

Features of the anemia at patients with Crohn’s disease
by: V. A. Akhmedov, et al.
Published: (2018-07-01)

Potential Vaccines for Treating Crohn\'s Disease
by: Mohammad Rostami-Nejad, et al.
Published: (2020-01-01)

The microbiome of Crohn’s disease aphthous ulcers
by: Claire L. O’Brien, et al.
Published: (2018-10-01)

Isolated Crohn’s disease of the esophagus with esophago-mediastinal fistula formation
by: Wang Wuping, et al.
Published: (2012-10-01)

Extraintestinal Crohn's disease (metastatic Crohn's disease)
by: Michał Rożalski
Published: (2014-10-01)

CASE OF CROHN’S DISEASE IN A CHILD WITH NODULAR PULMONARY TUBERCULOSIS
by: S. M. Kavtarashvili, et al.
Published: (2016-05-01)

Update of endoscopic management of Crohn’s disease strictures
by: Akshay Pokala, et al.
Published: (2020-01-01)

The risk of small bowel adenocarcinoma in patients with Crohn’s disease
by: Gustaw Lech, et al.
Published: (2020-12-01)

Pediatric Crohn’s Disease in Bahrain
by: Hasan M. Isa, et al.
Published: (2018-07-01)

Vulvar Crohn disease: Diagnostic challenges and approach to therapy
by: Bridget E. Shields, MD, et al.
Published: (2020-12-01)

Abdominal Surgery in Crohn’s Disease: Risk Factors for Complications
by: Cintia Mayumi Sakurai Kimura, et al.
Published: (2020-10-01)

Commentary: PET/MR Versus PET/CT Imaging: Impact on the Clinical Management of Small-Bowel Crohn’s Disease
by: Sophie James, et al.
Published: (2017-05-01)

A CLINICAL CASE OF CROHN’S DISEASE
by: Bohun N. Yu., et al.
Published: (2018-07-01)

Oropharyngeal Candidiasis as a Presenting Symptom of Crohn’s Disease
by: Muhammad Sharif, et al.
Published: (2020-04-01)

Efficacy and safety of adalimumab in the treatment of Crohn's disease in children
by: Víctor Manuel Navas-López, et al.
Published: (2013-12-01)

Tracheal Involvement in Crohn Disease: the First Case in Korea
by: Seunghyun Park, et al.
Published: (2016-03-01)

ORAL MANIFESTATIONS OF CROHN'S DISEASE: A CASE REPORT
by: Muhvić-Urek Miranda, et al.
Published: (2015-12-01)

Diaphragm Disease: NSAID-Induced Small Bowel Stricture
by: Bruce J. Grattan Jr., et al.
Published: (2018-06-01)