Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction channels, which may play a role in promoting atrial...

Full description

Bibliographic Details
Main Authors: Yiguo Sun, Matthew D Hills, Willy G Ye, Xiaoling Tong, Donglin Bai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3986259?pdf=render

Similar Items

Similar Items