Eye movement behavior identification for Alzheimer's disease diagnosis

We develop a deep-learning approach to differentiate between the eye movement behavior of people with neurodegenerative diseases during reading compared to healthy control subjects. The subjects with and without Alzheimer’s disease read well-defined and previously validated sentences including high-...

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Bibliographic Details
Main Author: Juan Biondi, Gerardo Fernandez, Silvia Castro, Osvaldo Agamennoni
Format: Article
Language:English
Published: IMR (Innovative Medical Research) Press Limited 2018-11-01
Series:Journal of Integrative Neuroscience
Subjects:
Online Access:https://jin.imrpress.com/fileup/1757-448X/PDF/1546069972927-1824017746.pdf
Description
Summary:We develop a deep-learning approach to differentiate between the eye movement behavior of people with neurodegenerative diseases during reading compared to healthy control subjects. The subjects with and without Alzheimer’s disease read well-defined and previously validated sentences including high- and low-predictable sentences, and proverbs. From these eye-tracking data trial-wise information is derived consisting of descriptors that capture the reading behavior of the subjects. With this information a set of denoising sparse-autoencoders are trained and a deep neural network is built using the trained autoencoders and a softmax classifier that identifies subjects with Alzheimer’s disease with 89.78% accuracy. The results are very encouraging and show that such models promise to be helpful for understanding the dynamics of eye movement behavior and its relation with underlying neuropsychological processes.
ISSN:1757-448X