Phase separation-deficient TDP43 remains functional in splicing

Phase separation-deficient TDP43 remains functional in splicing

TDP43 regulates RNA processing and undergoes liquid-liquid phase separation. Here, the authors combine bioinformatic analysis and quantitative measurements of phase properties in living cells to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and find that unex...

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Main Authors: Hermann Broder Schmidt, Ariana Barreau, Rajat Rohatgi
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12740-2
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spelling doaj-669a599713dd4365a9515ad591a4ae222021-05-11T12:28:50ZengNature Publishing GroupNature Communications2041-17232019-10-0110111410.1038/s41467-019-12740-2Phase separation-deficient TDP43 remains functional in splicingHermann Broder Schmidt0Ariana Barreau1Rajat Rohatgi2Department of Biochemistry, Stanford School of MedicineDepartment of Biochemistry, Stanford School of MedicineDepartment of Biochemistry, Stanford School of MedicineTDP43 regulates RNA processing and undergoes liquid-liquid phase separation. Here, the authors combine bioinformatic analysis and quantitative measurements of phase properties in living cells to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and find that unexpectedly, mutants of TDP43 that are deficient in phase separation can still function to mediate splicing.https://doi.org/10.1038/s41467-019-12740-2
collection DOAJ
language English
format Article
sources DOAJ
author Hermann Broder Schmidt
Ariana Barreau
Rajat Rohatgi
spellingShingle Hermann Broder Schmidt
Ariana Barreau
Rajat Rohatgi
Phase separation-deficient TDP43 remains functional in splicing
Nature Communications
author_facet Hermann Broder Schmidt
Ariana Barreau
Rajat Rohatgi
author_sort Hermann Broder Schmidt
title Phase separation-deficient TDP43 remains functional in splicing
title_short Phase separation-deficient TDP43 remains functional in splicing
title_full Phase separation-deficient TDP43 remains functional in splicing
title_fullStr Phase separation-deficient TDP43 remains functional in splicing
title_full_unstemmed Phase separation-deficient TDP43 remains functional in splicing
title_sort phase separation-deficient tdp43 remains functional in splicing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description TDP43 regulates RNA processing and undergoes liquid-liquid phase separation. Here, the authors combine bioinformatic analysis and quantitative measurements of phase properties in living cells to uncover the rules that link the amino acid sequence of TDP43 with its phase properties and find that unexpectedly, mutants of TDP43 that are deficient in phase separation can still function to mediate splicing.
url https://doi.org/10.1038/s41467-019-12740-2
work_keys_str_mv AT hermannbroderschmidt phaseseparationdeficienttdp43remainsfunctionalinsplicing
AT arianabarreau phaseseparationdeficienttdp43remainsfunctionalinsplicing
AT rajatrohatgi phaseseparationdeficienttdp43remainsfunctionalinsplicing
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