P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice

P-glycoprotein Inhibitor Tariquidar Potentiates Efficacy of Astragaloside IV in Experimental Autoimmune Encephalomyelitis Mice

ATP-binding cassette (ABC) transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), often reduce drug efficacy and are the major cause of drug resistance. Astragaloside IV (ASIV), one of the bioactive saponins isolated from <i>Astragalus membranaceus</i>,...

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Bibliographic Details
Main Authors: Wei Zhang, Mei Liu, Liu Yang, Fei Huang, Yunyi Lan, Hongli Li, Hui Wu, Beibei Zhang, Hailian Shi, Xiaojun Wu
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
astragaloside IV
P-glycoprotein
breast cancer resistance protein
blood–brain barrier
experimental autoimmune encephalomyelitis
tariquidar
Online Access:https://www.mdpi.com/1420-3049/24/3/561

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https://www.mdpi.com/1420-3049/24/3/561

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