Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD105 immunoliposomes

Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD105 immunoliposomes

Abstract Background Anti-CD105 mAb-conjugated immunoliposomes, loaded with secreted mouse endostatin gene, were developed for targeted tumor imaging and antiangiogenic gene therapy. Methods The liposomes were investigated for size, zeta-potential, lipid content, antibody binding ability, and pcDNA l...

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Bibliographic Details
Main Authors: Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong, Yongxiang Zhao
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Anti-CD105 immunoliposome
Tumor vascular targeting
In vivo imaging
Secreted endostatin
Gene therapy
Online Access:http://link.springer.com/article/10.1186/s13046-018-0712-8

Internet

http://link.springer.com/article/10.1186/s13046-018-0712-8

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