Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets

Modern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA) are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A numbe...

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Main Author:	T.V. Korotaeva
Format:	Article
Language:	Russian
Published:	IMA-PRESS LLC 2014-05-01
Series:	Современная ревматология
Subjects:	psoriatic arthritis psoriasis angiogenesis immunological mechanisms pro-angiogenic cytokines growth factors tumor necrosis factor α.
Online Access:	https://mrj.ima-press.net/mrj/article/view/550

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spelling	doaj-6682e5a68876419082b49ea3d87829742021-07-29T09:00:09ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2014-05-0182717510.14412/1996-7012-2014-2-71-751851Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targetsT.V. Korotaeva0V.A. Nasonova Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow, RussiaModern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA) are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A number of angiogenesis mediators, pro-angiogenic cytokines, growth factors, matrix metalloproteinases, etc. are shown to be involved in progression of neovascularization. The role of tumor necrosis factor α as a key therapeutic target for treatment of psoriasis and PsA is emphasized. Drugs inhibiting some stages of angiogenesis, which are either used in clinical practice or are being developed, are discussed.https://mrj.ima-press.net/mrj/article/view/550psoriatic arthritispsoriasisangiogenesisimmunological mechanismspro-angiogenic cytokinesgrowth factorstumor necrosis factor α.
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	T.V. Korotaeva
spellingShingle	T.V. Korotaeva Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets Современная ревматология psoriatic arthritis psoriasis angiogenesis immunological mechanisms pro-angiogenic cytokines growth factors tumor necrosis factor α.
author_facet	T.V. Korotaeva
author_sort	T.V. Korotaeva
title	Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets
title_short	Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets
title_full	Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets
title_fullStr	Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets
title_full_unstemmed	Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets
title_sort	angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets
publisher	IMA-PRESS LLC
series	Современная ревматология
issn	1996-7012 2310-158X
publishDate	2014-05-01
description	Modern concepts of the role of angiogenesis in pathogenesis of psoriasis and psoriatic arthritis (PsA) are analyzed. The features of cell-mediated and humoral immune responses resulting in proliferation of synovial membrane and vessel overgrowth in patients with this pathology are discussed. A number of angiogenesis mediators, pro-angiogenic cytokines, growth factors, matrix metalloproteinases, etc. are shown to be involved in progression of neovascularization. The role of tumor necrosis factor α as a key therapeutic target for treatment of psoriasis and PsA is emphasized. Drugs inhibiting some stages of angiogenesis, which are either used in clinical practice or are being developed, are discussed.
topic	psoriatic arthritis psoriasis angiogenesis immunological mechanisms pro-angiogenic cytokines growth factors tumor necrosis factor α.
url	https://mrj.ima-press.net/mrj/article/view/550
work_keys_str_mv	AT tvkorotaeva angiogenesisinpatientswithpsoriasisandpsoriaticarthritiscellmediatedandhumoralmechanismsitsroleinpathogenesisandsearchingforpromisingtherapeutictargets
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Angiogenesis in patients with psoriasis and psoriatic arthritis: cell-mediated and humoral mechanisms, its role in pathogenesis, and searching for promising therapeutic targets

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