Two 4N cell-cycle arrests contribute to cisplatin-resistance.

Cisplatin is a platinum-based drug that is used for the treatment of a wide-variety of primary human cancers. However, the therapeutic efficacy of cisplatin is often limited by intrinsic or acquired drug resistance. An important goal, therefore, is to identify mechanisms that lead to cisplatin resis...

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Bibliographic Details
Main Authors: Hong Shen, Ricardo E Perez, Batzaya Davaadelger, Carl G Maki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3613405?pdf=render

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