Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
Rheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction betwe...
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doaj-667eab42b93e4ba09e58b5cdf11201d42020-11-25T02:32:09ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01216201210.3390/ijms21062012ijms21062012Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune DisordersChary Lopez-Pedrera0Nuria Barbarroja1Alejandra Mª Patiño-Trives2Maria Luque-Tévar3Carmen Torres-Granados4Mª Angeles Aguirre-Zamorano5Eduardo Collantes-Estevez6Carlos Pérez-Sánchez7Rheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction between traditional CV-risk factors, immune deregulation and disease activity. Oxidative stress, dyslipidemia, endothelial dysfunction, inflammatory/prothrombotic mediators (cytokines/chemokines, adipokines, proteases, adhesion-receptors, NETosis-derived-products, and intracellular-signaling molecules) have been implicated in these vascular pathologies. Genetic and genomic analyses further allowed the identification of signatures explaining the pro-atherothrombotic profiles in RA, SLE and APS. However, gene modulation has left significant gaps in our understanding of CV co-morbidities in SADs. MicroRNAs (miRNAs) are emerging as key post-transcriptional regulators of a suite of signaling pathways and pathophysiological effects. Abnormalities in high number of miRNA and their associated functions have been described in several SADs, suggesting their involvement in the development of atherosclerosis and thrombosis in the setting of RA, SLE and APS. This review focusses on recent insights into the potential role of miRNAs both, as clinical biomarkers of atherosclerosis and thrombosis in SADs, and as therapeutic targets in the regulation of the most influential processes that govern those disorders, highlighting the potential diagnostic and therapeutic properties of miRNAs in the management of CVD.https://www.mdpi.com/1422-0067/21/6/2012systemic autoimmune diseasesantiphospholipid syndromesystemic lupus erythematosusrheumatoid arthritisatherosclerosisthrombosiscardiovascular diaseasemicrornas |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chary Lopez-Pedrera Nuria Barbarroja Alejandra Mª Patiño-Trives Maria Luque-Tévar Carmen Torres-Granados Mª Angeles Aguirre-Zamorano Eduardo Collantes-Estevez Carlos Pérez-Sánchez |
spellingShingle |
Chary Lopez-Pedrera Nuria Barbarroja Alejandra Mª Patiño-Trives Maria Luque-Tévar Carmen Torres-Granados Mª Angeles Aguirre-Zamorano Eduardo Collantes-Estevez Carlos Pérez-Sánchez Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders International Journal of Molecular Sciences systemic autoimmune diseases antiphospholipid syndrome systemic lupus erythematosus rheumatoid arthritis atherosclerosis thrombosis cardiovascular diasease micrornas |
author_facet |
Chary Lopez-Pedrera Nuria Barbarroja Alejandra Mª Patiño-Trives Maria Luque-Tévar Carmen Torres-Granados Mª Angeles Aguirre-Zamorano Eduardo Collantes-Estevez Carlos Pérez-Sánchez |
author_sort |
Chary Lopez-Pedrera |
title |
Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders |
title_short |
Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders |
title_full |
Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders |
title_fullStr |
Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders |
title_full_unstemmed |
Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders |
title_sort |
role of micrornas in the development of cardiovascular disease in systemic autoimmune disorders |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2020-03-01 |
description |
Rheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction between traditional CV-risk factors, immune deregulation and disease activity. Oxidative stress, dyslipidemia, endothelial dysfunction, inflammatory/prothrombotic mediators (cytokines/chemokines, adipokines, proteases, adhesion-receptors, NETosis-derived-products, and intracellular-signaling molecules) have been implicated in these vascular pathologies. Genetic and genomic analyses further allowed the identification of signatures explaining the pro-atherothrombotic profiles in RA, SLE and APS. However, gene modulation has left significant gaps in our understanding of CV co-morbidities in SADs. MicroRNAs (miRNAs) are emerging as key post-transcriptional regulators of a suite of signaling pathways and pathophysiological effects. Abnormalities in high number of miRNA and their associated functions have been described in several SADs, suggesting their involvement in the development of atherosclerosis and thrombosis in the setting of RA, SLE and APS. This review focusses on recent insights into the potential role of miRNAs both, as clinical biomarkers of atherosclerosis and thrombosis in SADs, and as therapeutic targets in the regulation of the most influential processes that govern those disorders, highlighting the potential diagnostic and therapeutic properties of miRNAs in the management of CVD. |
topic |
systemic autoimmune diseases antiphospholipid syndrome systemic lupus erythematosus rheumatoid arthritis atherosclerosis thrombosis cardiovascular diasease micrornas |
url |
https://www.mdpi.com/1422-0067/21/6/2012 |
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