Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders

Rheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction betwe...

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Main Authors: Chary Lopez-Pedrera, Nuria Barbarroja, Alejandra Mª Patiño-Trives, Maria Luque-Tévar, Carmen Torres-Granados, Mª Angeles Aguirre-Zamorano, Eduardo Collantes-Estevez, Carlos Pérez-Sánchez
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/6/2012
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spelling doaj-667eab42b93e4ba09e58b5cdf11201d42020-11-25T02:32:09ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-03-01216201210.3390/ijms21062012ijms21062012Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune DisordersChary Lopez-Pedrera0Nuria Barbarroja1Alejandra Mª Patiño-Trives2Maria Luque-Tévar3Carmen Torres-Granados4Mª Angeles Aguirre-Zamorano5Eduardo Collantes-Estevez6Carlos Pérez-Sánchez7Rheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatology Service, Reina Sofia Hospital/Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/University of Cordoba, E-14004 Córdoba, SpainRheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction between traditional CV-risk factors, immune deregulation and disease activity. Oxidative stress, dyslipidemia, endothelial dysfunction, inflammatory/prothrombotic mediators (cytokines/chemokines, adipokines, proteases, adhesion-receptors, NETosis-derived-products, and intracellular-signaling molecules) have been implicated in these vascular pathologies. Genetic and genomic analyses further allowed the identification of signatures explaining the pro-atherothrombotic profiles in RA, SLE and APS. However, gene modulation has left significant gaps in our understanding of CV co-morbidities in SADs. MicroRNAs (miRNAs) are emerging as key post-transcriptional regulators of a suite of signaling pathways and pathophysiological effects. Abnormalities in high number of miRNA and their associated functions have been described in several SADs, suggesting their involvement in the development of atherosclerosis and thrombosis in the setting of RA, SLE and APS. This review focusses on recent insights into the potential role of miRNAs both, as clinical biomarkers of atherosclerosis and thrombosis in SADs, and as therapeutic targets in the regulation of the most influential processes that govern those disorders, highlighting the potential diagnostic and therapeutic properties of miRNAs in the management of CVD.https://www.mdpi.com/1422-0067/21/6/2012systemic autoimmune diseasesantiphospholipid syndromesystemic lupus erythematosusrheumatoid arthritisatherosclerosisthrombosiscardiovascular diaseasemicrornas
collection DOAJ
language English
format Article
sources DOAJ
author Chary Lopez-Pedrera
Nuria Barbarroja
Alejandra Mª Patiño-Trives
Maria Luque-Tévar
Carmen Torres-Granados
Mª Angeles Aguirre-Zamorano
Eduardo Collantes-Estevez
Carlos Pérez-Sánchez
spellingShingle Chary Lopez-Pedrera
Nuria Barbarroja
Alejandra Mª Patiño-Trives
Maria Luque-Tévar
Carmen Torres-Granados
Mª Angeles Aguirre-Zamorano
Eduardo Collantes-Estevez
Carlos Pérez-Sánchez
Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
International Journal of Molecular Sciences
systemic autoimmune diseases
antiphospholipid syndrome
systemic lupus erythematosus
rheumatoid arthritis
atherosclerosis
thrombosis
cardiovascular diasease
micrornas
author_facet Chary Lopez-Pedrera
Nuria Barbarroja
Alejandra Mª Patiño-Trives
Maria Luque-Tévar
Carmen Torres-Granados
Mª Angeles Aguirre-Zamorano
Eduardo Collantes-Estevez
Carlos Pérez-Sánchez
author_sort Chary Lopez-Pedrera
title Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
title_short Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
title_full Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
title_fullStr Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
title_full_unstemmed Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders
title_sort role of micrornas in the development of cardiovascular disease in systemic autoimmune disorders
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2020-03-01
description Rheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are the systemic autoimmune diseases (SADs) most associated with an increased risk of developing cardiovascular (CV) events. Cardiovascular disease (CVD) in SADs results from a complex interaction between traditional CV-risk factors, immune deregulation and disease activity. Oxidative stress, dyslipidemia, endothelial dysfunction, inflammatory/prothrombotic mediators (cytokines/chemokines, adipokines, proteases, adhesion-receptors, NETosis-derived-products, and intracellular-signaling molecules) have been implicated in these vascular pathologies. Genetic and genomic analyses further allowed the identification of signatures explaining the pro-atherothrombotic profiles in RA, SLE and APS. However, gene modulation has left significant gaps in our understanding of CV co-morbidities in SADs. MicroRNAs (miRNAs) are emerging as key post-transcriptional regulators of a suite of signaling pathways and pathophysiological effects. Abnormalities in high number of miRNA and their associated functions have been described in several SADs, suggesting their involvement in the development of atherosclerosis and thrombosis in the setting of RA, SLE and APS. This review focusses on recent insights into the potential role of miRNAs both, as clinical biomarkers of atherosclerosis and thrombosis in SADs, and as therapeutic targets in the regulation of the most influential processes that govern those disorders, highlighting the potential diagnostic and therapeutic properties of miRNAs in the management of CVD.
topic systemic autoimmune diseases
antiphospholipid syndrome
systemic lupus erythematosus
rheumatoid arthritis
atherosclerosis
thrombosis
cardiovascular diasease
micrornas
url https://www.mdpi.com/1422-0067/21/6/2012
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