POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

Abstract Sterol-regulatory element binding proteins (SREBPs) are the key transcriptional regulators of lipid metabolism. The activation of SREBP requires translocation of the SREBP precursor from the endoplasmic reticulum to the Golgi, where it is sequentially cleaved by site-1 protease (S1P) and si...

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Bibliographic Details
Main Authors: Jian Xiao, Yanni Xiong, Liu-Ting Yang, Ju-Qiong Wang, Zi-Mu Zhou, Le-Wei Dong, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song
Format: Article
Language:English
Published: SpringerOpen 2020-07-01
Series:Protein & Cell
Subjects:
SREBP
site-1 protease
proteolytic activation
unfolded protein response
activating transcription factor 6
mannose-6-phosphate
Online Access:https://doi.org/10.1007/s13238-020-00753-3

Internet

https://doi.org/10.1007/s13238-020-00753-3

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