Mangiferin suppresses human metastatic osteosarcoma cell growth by down-regulating the expression of metalloproteinases-1/2 and parathyroid hormone receptor 1

Mangiferin suppresses human metastatic osteosarcoma cell growth by down-regulating the expression of metalloproteinases-1/2 and parathyroid hormone receptor 1

Abstract The study evaluates the protective effect of mangiferin on osteosarcoma cell proliferation and metastasis. Saos-2 and U2OS cells were treated with mangiferin (25, 50, 75 and 100 µM) for 72 h. Mangiferin reduced the cell viability, invasion, and cell adhesion and migration rate. Matrix metal...

Full description

Bibliographic Details
Main Authors: Jifeng Wen, Yong Qin, Chao Li, Xiankui Dai, Tong Wu, Wenzhe Yin
Format: Article
Language:English
Published: SpringerOpen 2020-01-01
Series:AMB Express
Subjects:
Mangiferin
Proliferation
Adhesion
Osteosarcoma
mRNA
Online Access:https://doi.org/10.1186/s13568-020-0949-4

Similar Items

Similar Items