Role of Peg10 in FAK-mediated CAM-DR in hepatocellular carcinoma

Role of Peg10 in FAK-mediated CAM-DR in hepatocellular carcinoma

ObjectiveTo preliminarily investigate the relationship of Peg10 with focal adhesion kinase (FAK)-mediated cell adhesion-mediated drug resistance (CAM-DR) in hepatocellular carcinoma (HCC), and to explore the underlying molecular mechanism. MethodsThe effects of 5-fluorouracil (5-Fu) and adriamycin (...

Full description

Bibliographic Details
Main Author:	ZHANG Hai
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Hepatology 2015-02-01
Series:	Linchuang Gandanbing Zazhi
Subjects:	liver neoplasms; focal adhesion protein-tyrosine kinases; Peg10 gene; drug resistance neoplasm; RNA small interfering
Online Access:	http://www.lcgdbzz.org/qk_content.asp?id=6279&ClassID=11415232

Similar Items

Inhibition of focal adhesion kinase enhances antitumor response of radiation therapy in pancreatic cancer through CD8+ T cells
by: Arsen Osipov, et al.
Published: (2021-02-01)

Novas quinazolinas 2,4,8-dissubstituídas com potencial atividade de inibição da quinase de adesão focal (FAK)
by: Antunes, João Eustáquio, 1971-
Published: (2013)

A chemical-biology approach for screening novel inhibitors of focal adhesion signaling in relation to breast cancer /
by: Cao, Yangxiezi.
Published: (2008)

Characterization of microRNAs in hepatocellular carcinoma.
Published: (2013)

Epigenetic deregulation of microRNAs in hepatocellular carcinoma.
Published: (2012)

The Role of the FAT Domain in Controlling Localization and Activation of the Focal Adhesion Kinase (FAK)
by: Naser, Rayan Mohammad Mahmoud
Published: (2019)

Involvement of the FAK Network in Pathologies Related to Altered Mechanotransduction
by: Enrica Urciuoli, et al.
Published: (2020-12-01)

The Tyrosine Kinase Pyk2 Promotes Migration and Invasion of Glioma Cells
by: Christopher A. Lipinski, et al.
Published: (2005-05-01)

Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma
by: Paola Francalanci, et al.
Published: (2020-08-01)

Caffeine Inhibits Migration in Glioma Cells through the ROCK-FAK Pathway
by: Ying Chen, et al.
Published: (2014-06-01)

FAK and SRC Kinases Maintain Integrin Activation During Endocytic Recycling to Polarize Adhesion Formation
by: Nader, Guilherme Pedreira de F.
Published: (2015)

FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis
by: Ioanna Antoniades, et al.
Published: (2021-01-01)

Estudos proteômicos revelam um novo papel da proteína FAK na regulação do splicing do mRNA
by: Cordeiro, Isabelle Bezerra, 1983-
Published: (2014)

Integrin VLA-5 and FAK are good targets to improve treatment response in the Philadelphia chromosome positive acute lymphoblastic leukemia
by: Zhongbo eHu, et al.
Published: (2014-05-01)

Evaluation of therapeutic effects of FAK inhibition in murine models of atherosclerosis
by: Takeshi Yamaura, et al.
Published: (2019-04-01)

Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy
by: Xiao-Jing Pang, et al.
Published: (2021-07-01)

FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions
by: Paula Tapial Martínez, et al.
Published: (2020-01-01)

FAK Modulates Cell Adhesion Strengthening Via Two Distinct Mechanisms: Integrin Binding and Vinculin Localization
by: Michael, Kristin E.
Published: (2007)

High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site
by: Timothy Marlowe, et al.
Published: (2019-05-01)

Experience of Hepatocellular Cancer Therapy with Multikinase Inhibitors in the Republic of Bashkortostan
by: Sh. Kh. Gantsev, et al.
Published: (2020-11-01)

Graphene-Induced Osteogenic Differentiation Is Mediated by the Integrin/FAK Axis
by: Han Xie, et al.
Published: (2019-01-01)

Roles of hypoxia-inducible microRNA-210 in hepatocellular carcinoma
by: Kai, Ka-lun, Alan, et al.
Published: (2014)

Research Progress of Small Molecule Anti-angiogenic Drugs  in Non-small Cell Lung Cancer
by: Yan DOU, et al.
Published: (2021-01-01)

Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence
by: Hsiang-Hao Chuang, et al.
Published: (2019-01-01)

Silencing of rhomboid domain containing 1 to inhibit the metastasis of human breast cancer cells in vitro
by: Chunjun Huang, et al.
Published: (2018-11-01)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
by: Wang Wenqi, et al.
Published: (2011-11-01)

Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo
by: Marija Nešović, et al.
Published: (2020-06-01)

Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling
by: Jaymin J. Kathiriya, et al.
Published: (2017-02-01)

Pharmacological inhibition of focal adhesion kinase 1 (FAK1) and anaplastic lymphoma kinase (ALK) identified via kinome profile analysis attenuates lipopolysaccharide-induced endothelial inflammatory activation
by: Erna-Zulaikha Dayang, et al.
Published: (2021-01-01)

Adenine Inhibits the Invasive Potential of DLD-1 Human Colorectal Cancer Cell via the AMPK/FAK Axis
by: Chien-Wei Huang, et al.
Published: (2021-08-01)

Atovaquone Suppresses the Growth of Metastatic Triple-Negative Breast Tumors in Lungs and Brain by Inhibiting Integrin/FAK Signaling Axis
by: Nehal Gupta, et al.
Published: (2021-05-01)

Berberine Attenuates Macrophages Infiltration in Intracranial Aneurysms Potentially Through FAK/Grp78/UPR Axis
by: Kai Quan, et al.
Published: (2018-05-01)

ZINC40099027 activates human focal adhesion kinase by accelerating the enzymatic activity of the FAK kinase domain
by: Rashmi, et al.
Published: (2021-04-01)

Activation of Rho-kinase and focal adhesion kinase regulates the organization of stress fibers and focal adhesions in the central part of fibroblasts
by: Kazuo Katoh
Published: (2017-11-01)

The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells
by: Valerie G. Brunton, et al.
Published: (2001-01-01)

A case of primary hepatocellular carcinoma with lung adenocarcinoma and liver metastasis
by: WANG Le, et al.
Published: (2017-04-01)

The roles of microRNA-200 family in ovarian cancer development.
Published: (2013)

MicroRNAs associated with granulin-epithelin precursor in hepatocellular carcinoma
by: Lau, Pok, et al.
Published: (2014)

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy
by: Carlos J Diaz Osterman, et al.
Published: (2019-09-01)

Norcantharidin Suppresses YD-15 Cell Invasion Through Inhibition of FAK/Paxillin and F-Actin Reorganization
by: Kyoung-Ok Hong, et al.
Published: (2019-05-01)