GATA3 Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population

• Main Authors: Afshin Shirkani, Atena Mansouri, Mohammad Reza Abbaszadegan, Reza Faridhosseini, Farahzad Jabbari Azad, Mehran Gholamin
• Format: Article
• Language: English
• Published: Varastegan Institute for Medical Sciences 2017-05-01
• Series: Reports of Biochemistry and Molecular Biology
• Subjects: Allergic rhinitis; GATA3; Genetic; SNP
• Online Access: http://rbmb.net/article-1-108-en.pdf

Background: The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified. Methods: This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to evaluate a potential association between two GATA3 SNPs, rs1269486 and rs2229360, and AR. Blood samples were collected and DNA was extracted for the evaluation of these SNPs by RFLP-PCR. Results: A statistically-significant association was found between rs1269486 and AR (P<0.001). The frequencies of the A and GA genotypes were less in patients than in controls. The frequencies of the G allele and the GG genotype were greater in patients than in controls (P < 0.001). Conclusions: SNP rs1269486 of GATA3 was associated with AR and sensitivity to aeroallergens in our population. Because of the significance of this gene in AR, studying the association between GATA3 polymorphisms and AR is recommended for other populations.