Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry...
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.650793/full |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Weinan Zhao Weinan Zhao Weinan Zhao Qing Li Qing Li Qing Li Qing Li Qing Li Qing Li Yu Ma Yu Ma Yu Ma Zhiyong Wang Zhiyong Wang Zhiyong Wang Bingqian Fan Bingqian Fan Bingqian Fan Xiaojing Zhai Xiaojing Zhai Xiaojing Zhai Mengfan Hu Mengfan Hu Mengfan Hu Mengfan Hu Qing Wang Qing Wang Qing Wang Qing Wang Moruo Zhang Moruo Zhang Moruo Zhang Moruo Zhang Chunyan Zhang Chunyan Zhang Chunyan Zhang Chunyan Zhang Yixue Qin Yixue Qin Yixue Qin Yixue Qin Sha Sha Sha Sha Sha Sha Sha Sha Zhonghao Gan Zhonghao Gan Zhonghao Gan Zhonghao Gan Fan Ye Yihan Xia Guangchao Zhang Guangchao Zhang Guangchao Zhang Li Yang Li Yang Li Yang Shiya Zou Shiya Zou Shiya Zou Zheng Xu Zheng Xu Zheng Xu Sunhui Xia Sunhui Xia Sunhui Xia Yumei Yu Yumei Yu Yumei Yu Mannan Abdul Mannan Abdul Mannan Abdul Mannan Abdul Jun-Xia Yang Jun-Xia Yang Jun-Xia Yang Jun-Li Cao Jun-Li Cao Jun-Li Cao Jun-Li Cao Fang Zhou Hongxing Zhang Hongxing Zhang Hongxing Zhang |
| spellingShingle |
Weinan Zhao Weinan Zhao Weinan Zhao Qing Li Qing Li Qing Li Qing Li Qing Li Qing Li Yu Ma Yu Ma Yu Ma Zhiyong Wang Zhiyong Wang Zhiyong Wang Bingqian Fan Bingqian Fan Bingqian Fan Xiaojing Zhai Xiaojing Zhai Xiaojing Zhai Mengfan Hu Mengfan Hu Mengfan Hu Mengfan Hu Qing Wang Qing Wang Qing Wang Qing Wang Moruo Zhang Moruo Zhang Moruo Zhang Moruo Zhang Chunyan Zhang Chunyan Zhang Chunyan Zhang Chunyan Zhang Yixue Qin Yixue Qin Yixue Qin Yixue Qin Sha Sha Sha Sha Sha Sha Sha Sha Zhonghao Gan Zhonghao Gan Zhonghao Gan Zhonghao Gan Fan Ye Yihan Xia Guangchao Zhang Guangchao Zhang Guangchao Zhang Li Yang Li Yang Li Yang Shiya Zou Shiya Zou Shiya Zou Zheng Xu Zheng Xu Zheng Xu Sunhui Xia Sunhui Xia Sunhui Xia Yumei Yu Yumei Yu Yumei Yu Mannan Abdul Mannan Abdul Mannan Abdul Mannan Abdul Jun-Xia Yang Jun-Xia Yang Jun-Xia Yang Jun-Li Cao Jun-Li Cao Jun-Li Cao Jun-Li Cao Fang Zhou Hongxing Zhang Hongxing Zhang Hongxing Zhang Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle Frontiers in Neuroscience estrous cycle female mice psychiatry pain behavior |
| author_facet |
Weinan Zhao Weinan Zhao Weinan Zhao Qing Li Qing Li Qing Li Qing Li Qing Li Qing Li Yu Ma Yu Ma Yu Ma Zhiyong Wang Zhiyong Wang Zhiyong Wang Bingqian Fan Bingqian Fan Bingqian Fan Xiaojing Zhai Xiaojing Zhai Xiaojing Zhai Mengfan Hu Mengfan Hu Mengfan Hu Mengfan Hu Qing Wang Qing Wang Qing Wang Qing Wang Moruo Zhang Moruo Zhang Moruo Zhang Moruo Zhang Chunyan Zhang Chunyan Zhang Chunyan Zhang Chunyan Zhang Yixue Qin Yixue Qin Yixue Qin Yixue Qin Sha Sha Sha Sha Sha Sha Sha Sha Zhonghao Gan Zhonghao Gan Zhonghao Gan Zhonghao Gan Fan Ye Yihan Xia Guangchao Zhang Guangchao Zhang Guangchao Zhang Li Yang Li Yang Li Yang Shiya Zou Shiya Zou Shiya Zou Zheng Xu Zheng Xu Zheng Xu Sunhui Xia Sunhui Xia Sunhui Xia Yumei Yu Yumei Yu Yumei Yu Mannan Abdul Mannan Abdul Mannan Abdul Mannan Abdul Jun-Xia Yang Jun-Xia Yang Jun-Xia Yang Jun-Li Cao Jun-Li Cao Jun-Li Cao Jun-Li Cao Fang Zhou Hongxing Zhang Hongxing Zhang Hongxing Zhang |
| author_sort |
Weinan Zhao |
| title |
Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle |
| title_short |
Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle |
| title_full |
Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle |
| title_fullStr |
Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle |
| title_full_unstemmed |
Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous Cycle |
| title_sort |
behaviors related to psychiatric disorders and pain perception in c57bl/6j mice during different phases of estrous cycle |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Neuroscience |
| issn |
1662-453X |
| publishDate |
2021-04-01 |
| description |
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry- and pain-related behaviors are examined under physiological condition in female C57BL/6J mice over different estrous cycle phases: proestrus, estrous, metestrous, diestrous. Our behavioral results reveal that there is no significant difference over different phases of the estrous cycle in social interaction test, sucrose preference test, tail suspension test, open field test, marble burying test, novelty-suppressed feeding test, Hargreaves thermal pain test, and Von Frey mechanical pain test. These findings implicate those psychiatry- and pain-related behaviors in normal female C57BL/6J mice appear to be relatively consistent throughout the estrous cycle; the estrous cycle might not be a main contributor to female C57BL/6J mice’s variability of behaviors. |
| topic |
estrous cycle female mice psychiatry pain behavior |
| url |
https://www.frontiersin.org/articles/10.3389/fnins.2021.650793/full |
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doaj-6668a1943e784e9e9d2e6343e44da1a52021-04-06T06:01:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-04-011510.3389/fnins.2021.650793650793Behaviors Related to Psychiatric Disorders and Pain Perception in C57BL/6J Mice During Different Phases of Estrous CycleWeinan Zhao0Weinan Zhao1Weinan Zhao2Qing Li3Qing Li4Qing Li5Qing Li6Qing Li7Qing Li8Yu Ma9Yu Ma10Yu Ma11Zhiyong Wang12Zhiyong Wang13Zhiyong Wang14Bingqian Fan15Bingqian Fan16Bingqian Fan17Xiaojing Zhai18Xiaojing Zhai19Xiaojing Zhai20Mengfan Hu21Mengfan Hu22Mengfan Hu23Mengfan Hu24Qing Wang25Qing Wang26Qing Wang27Qing Wang28Moruo Zhang29Moruo Zhang30Moruo Zhang31Moruo Zhang32Chunyan Zhang33Chunyan Zhang34Chunyan Zhang35Chunyan Zhang36Yixue Qin37Yixue Qin38Yixue Qin39Yixue Qin40Sha Sha41Sha Sha42Sha Sha43Sha Sha44Zhonghao Gan45Zhonghao Gan46Zhonghao Gan47Zhonghao Gan48Fan Ye49Yihan Xia50Guangchao Zhang51Guangchao Zhang52Guangchao Zhang53Li Yang54Li Yang55Li Yang56Shiya Zou57Shiya Zou58Shiya Zou59Zheng Xu60Zheng Xu61Zheng Xu62Sunhui Xia63Sunhui Xia64Sunhui Xia65Yumei Yu66Yumei Yu67Yumei Yu68Mannan Abdul69Mannan Abdul70Mannan Abdul71Mannan Abdul72Jun-Xia Yang73Jun-Xia Yang74Jun-Xia Yang75Jun-Li Cao76Jun-Li Cao77Jun-Li Cao78Jun-Li Cao79Fang Zhou80Hongxing Zhang81Hongxing Zhang82Hongxing Zhang83Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Nursing, Xuzhou Medical University, Xuzhou, ChinaDepartment of Nursing, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaDepartment of Intensive Care Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaSchool of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaThe First Medical College, Xuzhou Medical University, Xuzhou, ChinaThe First Medical College, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaDepartment of Anesthesiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaSchool of Nursing, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, ChinaJiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou, ChinaNMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, ChinaRobust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research is relatively rare due to an unchecked potential behavioral variation over the estrous cycle. In the present study, a battery of psychiatry- and pain-related behaviors are examined under physiological condition in female C57BL/6J mice over different estrous cycle phases: proestrus, estrous, metestrous, diestrous. Our behavioral results reveal that there is no significant difference over different phases of the estrous cycle in social interaction test, sucrose preference test, tail suspension test, open field test, marble burying test, novelty-suppressed feeding test, Hargreaves thermal pain test, and Von Frey mechanical pain test. These findings implicate those psychiatry- and pain-related behaviors in normal female C57BL/6J mice appear to be relatively consistent throughout the estrous cycle; the estrous cycle might not be a main contributor to female C57BL/6J mice’s variability of behaviors.https://www.frontiersin.org/articles/10.3389/fnins.2021.650793/fullestrous cyclefemale micepsychiatrypainbehavior |