Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model

Intrastriatal convection-enhanced delivery results in widespread perivascular distribution in a pre-clinical model

<p>Abstract</p> <p>Background</p> <p>Convection-enhanced delivery (CED), a direct method for drug delivery to the brain through intraparenchymal microcatheters, is a promising strategy for intracerebral pharmacological therapy. By establishing a pressure gradient at the...

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Bibliographic Details
Main Authors: Barua Neil U, Bienemann Alison S, Hesketh Shirley, Wyatt Marcella J, Castrique Emma, Love Seth, Gill Steven S
Format: Article
Language:English
Published: BMC 2012-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Convection-enhanced delivery
dextrans
solutes
perivascular
macrophages
nanoparticles
Online Access:http://www.fluidsbarrierscns.com/content/9/1/2

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