Design, Synthesis and Evaluation of N13-Substituted Evodiamine Derivatives against Human Cancer Cell Lines

Design, Synthesis and Evaluation of N13-Substituted Evodiamine Derivatives against Human Cancer Cell Lines

Attempting to improve the anticancer activity and solubility of evodiamine in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) solutions, thirty-eight N13-substituted evodiamine derivatives were designed, synthesized and tested for antitumor activities against six kinds of human ca...

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Bibliographic Details
Main Authors: Senchuan Song, Zhiyong Chen, Shaoxue Li, Yanmin Huang, Yiqian Wan, Huacan Song
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
N13-substituted evodiamine derivatives
antitumor activity
apoptosis
solubility
Online Access:http://www.mdpi.com/1420-3049/18/12/15750

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