High immune cytolytic activity in tumor‐free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

High immune cytolytic activity in tumor‐free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue

Abstract Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investi...

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Bibliographic Details
Main Authors: Xiaolian Gu, Linda Boldrup, Philip J Coates, Robin Fahraeus, Lixiao Wang, Torben Wilms, Lena Norberg‐Spaak, Nicola Sgaramella, Karin Nylander
Format: Article
Language:English
Published: Wiley 2019-10-01
Series:The Journal of Pathology: Clinical Research
Subjects:
cytolytic activity
squamous cell carcinoma
oral tongue
prognosis
Online Access:https://doi.org/10.1002/cjp2.138

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