Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

• Main Authors: Hiren H. Variya, Vikram Panchal, Ganpat.R. Patel
• Format: Article
• Language: English
• Published: Growing Science 2019-06-01
• Series: Current Chemistry Letters
• Subjects: Sulfonamide; 1H-pyarazolo[3; 4-b]pyridin Antioxidant Anti-bacterial activity Spectral studies
• Online Access: http://www.growingscience.com/ccl/Vol8/ccl_2019_16.pdf

A series of novel 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine linked various sulfonamide derivatives <b>8a-8j</b> poly functionalized were designed and synthesized in moderate to good yield. A starting with iodination of 5-Bromo-1H-pyrazolo[3,4-b]pyridine 5 with iodine produced intermediate 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine 6 with the reaction of various sulfonamide derivatives <b>7a-7j</b> via copper catalyzed coupling reaction produced targeted compounds<b>8a-8j</b>. The isolated compounds were accepted by spectral and elemental analysis. The compounds <b>8a,8c,8d,</b> and <b>8i</b> were excellent active against Gram-positive and gram-negative bacterial strain compare to streptomycin standard drug. All synthesized compounds showed moderate to good antioxidant properties with used DPPH and Superoxide radical scavenging assay, Compounds <b>8c, 8g, and 8i</b> exerted significant antioxidant scavenging activity for the DPPH radical.