Sedentary Life and Reduced Mastication Impair Spatial Learning and Memory and Differentially Affect Dentate Gyrus Astrocyte Subtypes in the Aged Mice

To explore the impact of reduced mastication and a sedentary lifestyle on spatial learning and memory in the aged mice, as well as on the morphology of astrocytes in the molecular layer of dentate gyrus (MolDG), different masticatory regimens were imposed. Control mice received a pellet-type hard di...

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Main Authors: Fabíola de Carvalho Chaves de Siqueira Mendes, Luisa Taynah Vasconcelos Barbosa Paixão, Daniel Guerreiro Diniz, Daniel Clive Anthony, Dora Brites, Cristovam Wanderley Picanço Diniz, Marcia Consentino Kronka Sosthenes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.632216/full