Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines
New DNA sequencing platforms have revolutionized human genome sequencing. The dramatic advances in genome sequencing technologies predict that the $1,000 genome will become a reality within the next few years. Applied to cancer, the availability of cancer genome sequences permits real-time decision-...
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| Format: | Article |
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MDPI AG
2011-11-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/3/4/4191/ |
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doaj-664cd06bfcd94093b69b7aedd28c1d982020-11-24T22:45:15ZengMDPI AGCancers2072-66942011-11-01344191421110.3390/cancers3044191Cancer Genome Sequencing and Its Implications for Personalized Cancer VaccinesWilliam E. GillandersTed H. HansenBeatriz M. CarrenoTimothy P. FlemingJohn M. HerndonXiuli ZhangMatthew J.C. EllisElaine R. MardisLijin LiPeter GoedegebuureNew DNA sequencing platforms have revolutionized human genome sequencing. The dramatic advances in genome sequencing technologies predict that the $1,000 genome will become a reality within the next few years. Applied to cancer, the availability of cancer genome sequences permits real-time decision-making with the potential to affect diagnosis, prognosis, and treatment, and has opened the door towards personalized medicine. A promising strategy is the identification of mutated tumor antigens, and the design of personalized cancer vaccines. Supporting this notion are preliminary analyses of the epitope landscape in breast cancer suggesting that individual tumors express significant numbers of novel antigens to the immune system that can be specifically targeted through cancer vaccines.http://www.mdpi.com/2072-6694/3/4/4191/cancer genome sequencingunique tumor antigenDNA vaccine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
William E. Gillanders Ted H. Hansen Beatriz M. Carreno Timothy P. Fleming John M. Herndon Xiuli Zhang Matthew J.C. Ellis Elaine R. Mardis Lijin Li Peter Goedegebuure |
| spellingShingle |
William E. Gillanders Ted H. Hansen Beatriz M. Carreno Timothy P. Fleming John M. Herndon Xiuli Zhang Matthew J.C. Ellis Elaine R. Mardis Lijin Li Peter Goedegebuure Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines Cancers cancer genome sequencing unique tumor antigen DNA vaccine |
| author_facet |
William E. Gillanders Ted H. Hansen Beatriz M. Carreno Timothy P. Fleming John M. Herndon Xiuli Zhang Matthew J.C. Ellis Elaine R. Mardis Lijin Li Peter Goedegebuure |
| author_sort |
William E. Gillanders |
| title |
Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines |
| title_short |
Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines |
| title_full |
Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines |
| title_fullStr |
Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines |
| title_full_unstemmed |
Cancer Genome Sequencing and Its Implications for Personalized Cancer Vaccines |
| title_sort |
cancer genome sequencing and its implications for personalized cancer vaccines |
| publisher |
MDPI AG |
| series |
Cancers |
| issn |
2072-6694 |
| publishDate |
2011-11-01 |
| description |
New DNA sequencing platforms have revolutionized human genome sequencing. The dramatic advances in genome sequencing technologies predict that the $1,000 genome will become a reality within the next few years. Applied to cancer, the availability of cancer genome sequences permits real-time decision-making with the potential to affect diagnosis, prognosis, and treatment, and has opened the door towards personalized medicine. A promising strategy is the identification of mutated tumor antigens, and the design of personalized cancer vaccines. Supporting this notion are preliminary analyses of the epitope landscape in breast cancer suggesting that individual tumors express significant numbers of novel antigens to the immune system that can be specifically targeted through cancer vaccines. |
| topic |
cancer genome sequencing unique tumor antigen DNA vaccine |
| url |
http://www.mdpi.com/2072-6694/3/4/4191/ |
| work_keys_str_mv |
AT williamegillanders cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT tedhhansen cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT beatrizmcarreno cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT timothypfleming cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT johnmherndon cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT xiulizhang cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT matthewjcellis cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT elainermardis cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT lijinli cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines AT petergoedegebuure cancergenomesequencinganditsimplicationsforpersonalizedcancervaccines |
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