Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma

An age of 70-year-old man was incidentally found two focal high 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in the descending colon and in the sigmoid colon. We observed the feature of these two areas in the preplanned 4′-[methyl-11C]-thiothymidine (4DST) positron emission tomography (PET)/compute...

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Main Authors: Ryogo Minamimoto, Hisako Endo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Diagnostics
Subjects:
Online Access:https://www.mdpi.com/2075-4418/11/9/1658
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spelling doaj-66434349af1140359be78bb35bfb28b52021-09-25T23:59:19ZengMDPI AGDiagnostics2075-44182021-09-01111658165810.3390/diagnostics11091658Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and AdenomaRyogo Minamimoto0Hisako Endo1Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, Tokyo 1628655, JapanDepartment of Clinical Pathology, Edogawa Hospital, Tokyo 1330052, JapanAn age of 70-year-old man was incidentally found two focal high 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in the descending colon and in the sigmoid colon. We observed the feature of these two areas in the preplanned 4′-[methyl-11C]-thiothymidine (4DST) positron emission tomography (PET)/computed Tomography (CT)providing cell proliferation imaging. A mass forming high 4DST uptake in the descending colon and focal moderate 4DST uptake in the sigmoid colon was confirmed, and that were proven pathologically as adenocarcinoma and moderate to severe type tubular adenoma, respectively. This is the first report to present that colorectal adenoma can be visualized by proliferation PET imaging and the degree of uptake may enable discrimination of colorectal adenoma from adenocarcinoma, based on pathological considerations.https://www.mdpi.com/2075-4418/11/9/16584DST PET/CTcolorectal adenomacolorectal adenocarcinomaFDG PET/CTcell proliferation imaging
collection DOAJ
language English
format Article
sources DOAJ
author Ryogo Minamimoto
Hisako Endo
spellingShingle Ryogo Minamimoto
Hisako Endo
Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma
Diagnostics
4DST PET/CT
colorectal adenoma
colorectal adenocarcinoma
FDG PET/CT
cell proliferation imaging
author_facet Ryogo Minamimoto
Hisako Endo
author_sort Ryogo Minamimoto
title Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma
title_short Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma
title_full Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma
title_fullStr Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma
title_full_unstemmed Cell Proliferation PET Imaging with 4DST PET/CT in Colorectal Adenocarcinoma and Adenoma
title_sort cell proliferation pet imaging with 4dst pet/ct in colorectal adenocarcinoma and adenoma
publisher MDPI AG
series Diagnostics
issn 2075-4418
publishDate 2021-09-01
description An age of 70-year-old man was incidentally found two focal high 2-[18F]-fluoro-2-deoxy-d-glucose (FDG) uptake in the descending colon and in the sigmoid colon. We observed the feature of these two areas in the preplanned 4′-[methyl-11C]-thiothymidine (4DST) positron emission tomography (PET)/computed Tomography (CT)providing cell proliferation imaging. A mass forming high 4DST uptake in the descending colon and focal moderate 4DST uptake in the sigmoid colon was confirmed, and that were proven pathologically as adenocarcinoma and moderate to severe type tubular adenoma, respectively. This is the first report to present that colorectal adenoma can be visualized by proliferation PET imaging and the degree of uptake may enable discrimination of colorectal adenoma from adenocarcinoma, based on pathological considerations.
topic 4DST PET/CT
colorectal adenoma
colorectal adenocarcinoma
FDG PET/CT
cell proliferation imaging
url https://www.mdpi.com/2075-4418/11/9/1658
work_keys_str_mv AT ryogominamimoto cellproliferationpetimagingwith4dstpetctincolorectaladenocarcinomaandadenoma
AT hisakoendo cellproliferationpetimagingwith4dstpetctincolorectaladenocarcinomaandadenoma
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