Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli
<abstract language="eng">QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E. coli cells were carried out applying factorial design. Results for both series showed a linear relationship betwe...
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Sociedade Brasileira de Química
1997-04-01
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doaj-663edf74e01e45b2bf4750e8c04986a92020-11-24T23:46:20ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70641997-04-0120212513110.1590/S0100-40421997000200002Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coliP. L. O. VolpeC. A. Montanari<abstract language="eng">QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E. coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log Po/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000200002biological microcalorimetryQSARbiological responsehomologous series |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
P. L. O. Volpe C. A. Montanari |
spellingShingle |
P. L. O. Volpe C. A. Montanari Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli Química Nova biological microcalorimetry QSAR biological response homologous series |
author_facet |
P. L. O. Volpe C. A. Montanari |
author_sort |
P. L. O. Volpe |
title |
Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli |
title_short |
Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli |
title_full |
Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli |
title_fullStr |
Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli |
title_full_unstemmed |
Estudos de QSAR baseados em dados de atividade biológica obtidos por microcalorimetria: III interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com Escherichia coli QSAR based on biological microcalorimetry: III interaction of m-alcoxy-phenols and p-hydroxybenzoates with Escherichia coli |
title_sort |
estudos de qsar baseados em dados de atividade biológica obtidos por microcalorimetria: iii interação de m-alcoxifenóis e p-hidroxibenzoatos de alquila com escherichia coli qsar based on biological microcalorimetry: iii interaction of m-alcoxy-phenols and p-hydroxybenzoates with escherichia coli |
publisher |
Sociedade Brasileira de Química |
series |
Química Nova |
issn |
0100-4042 1678-7064 |
publishDate |
1997-04-01 |
description |
<abstract language="eng">QSAR studies based on flow microcalorimetric bioassay data for interaction of homologous series of m-alkoxyphenols and p-hydroxybenzoates with E. coli cells were carried out applying factorial design. Results for both series showed a linear relationship between log(dose)max and log Po/w. Analysis of these data allows the identification of contributions toward the derived bioactivity from the parent structures (the molecule minus n-CH2 groups present in the side-chain) and the lipophilic groups, CH2. These results are discussed with respect to drug quantitative structure-relationship. |
topic |
biological microcalorimetry QSAR biological response homologous series |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000200002 |
work_keys_str_mv |
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