The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box–Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studi...

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Bibliographic Details
Main Authors: Emilia Szymańska, Katarzyna Woś-Latosi, Julia Jacyna, Magdalena Dąbrowska, Joanna Potaś, Michał Jan Markuszewski, Katarzyna Winnicka
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
microparticles
chitosan glutamate
drug release
ion crosslinker
zidovudine
Online Access:https://www.mdpi.com/1999-4923/12/5/455

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