Epidemic enhancement in partially immune populations.

Epidemic enhancement in partially immune populations.

We observe that a pathogen introduced into a population containing individuals with acquired immunity can result in an epidemic longer in duration and/or larger in size than if the pathogen were introduced into a naive population. We call this phenomenon "epidemic enhancement," and use sim...

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Main Authors: Juliet R C Pulliam, Jonathan G Dushoff, Simon A Levin, Andrew P Dobson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1769520?pdf=render
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spelling doaj-662ddb8b5718417499ca4eeb8dd3b1252020-11-25T01:44:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032007-01-0121e16510.1371/journal.pone.0000165Epidemic enhancement in partially immune populations.Juliet R C PulliamJonathan G DushoffSimon A LevinAndrew P DobsonWe observe that a pathogen introduced into a population containing individuals with acquired immunity can result in an epidemic longer in duration and/or larger in size than if the pathogen were introduced into a naive population. We call this phenomenon "epidemic enhancement," and use simple dynamical models to show that it is a realistic scenario within the parameter ranges of many common infectious diseases. This finding implies that repeated pathogen introduction or intermediate levels of vaccine coverage can lead to pathogen persistence in populations where extinction would otherwise be expected.http://europepmc.org/articles/PMC1769520?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Juliet R C Pulliam
Jonathan G Dushoff
Simon A Levin
Andrew P Dobson
spellingShingle Juliet R C Pulliam
Jonathan G Dushoff
Simon A Levin
Andrew P Dobson
Epidemic enhancement in partially immune populations.
PLoS ONE
author_facet Juliet R C Pulliam
Jonathan G Dushoff
Simon A Levin
Andrew P Dobson
author_sort Juliet R C Pulliam
title Epidemic enhancement in partially immune populations.
title_short Epidemic enhancement in partially immune populations.
title_full Epidemic enhancement in partially immune populations.
title_fullStr Epidemic enhancement in partially immune populations.
title_full_unstemmed Epidemic enhancement in partially immune populations.
title_sort epidemic enhancement in partially immune populations.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2007-01-01
description We observe that a pathogen introduced into a population containing individuals with acquired immunity can result in an epidemic longer in duration and/or larger in size than if the pathogen were introduced into a naive population. We call this phenomenon "epidemic enhancement," and use simple dynamical models to show that it is a realistic scenario within the parameter ranges of many common infectious diseases. This finding implies that repeated pathogen introduction or intermediate levels of vaccine coverage can lead to pathogen persistence in populations where extinction would otherwise be expected.
url http://europepmc.org/articles/PMC1769520?pdf=render
work_keys_str_mv AT julietrcpulliam epidemicenhancementinpartiallyimmunepopulations
AT jonathangdushoff epidemicenhancementinpartiallyimmunepopulations
AT simonalevin epidemicenhancementinpartiallyimmunepopulations
AT andrewpdobson epidemicenhancementinpartiallyimmunepopulations
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