Why do some T cell receptor cytoplasmic domains associate with the plasma membrane?

Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signalling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed mem...

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Bibliographic Details
Main Authors: Philip Anton evan der Merwe, Hao eZhang, Shaun-Paul eCordoba
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-02-01
Series:Frontiers in Immunology
Subjects:
tcr
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00029/full