Synthesis and characterization of new amino acyl-4-thiazolidones
A series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazoli...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2007-04-01
|
| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200008 |
| id |
doaj-661a34f2e7c143968fa4a5a9811ca4da |
|---|---|
| record_format |
Article |
| spelling |
doaj-661a34f2e7c143968fa4a5a9811ca4da2020-11-25T00:16:47ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642007-04-0130228428610.1590/S0100-40422007000200008Synthesis and characterization of new amino acyl-4-thiazolidonesAna Cristina Lima LeiteLuciene Maria F. SantosDiogo Rodrigo de M. MoreiraDalci José BrondaniA series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazolidone and the alpha-amino acid condensation reactions were carried out using strategies for peptide synthesis. The characterization of this new class of compounds was performed using IR and ¹H-NMR spectroscopy.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-404220070002000084-thiazolidonepeptidyl derivativesheterocyclic compounds |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Ana Cristina Lima Leite Luciene Maria F. Santos Diogo Rodrigo de M. Moreira Dalci José Brondani |
| spellingShingle |
Ana Cristina Lima Leite Luciene Maria F. Santos Diogo Rodrigo de M. Moreira Dalci José Brondani Synthesis and characterization of new amino acyl-4-thiazolidones Química Nova 4-thiazolidone peptidyl derivatives heterocyclic compounds |
| author_facet |
Ana Cristina Lima Leite Luciene Maria F. Santos Diogo Rodrigo de M. Moreira Dalci José Brondani |
| author_sort |
Ana Cristina Lima Leite |
| title |
Synthesis and characterization of new amino acyl-4-thiazolidones |
| title_short |
Synthesis and characterization of new amino acyl-4-thiazolidones |
| title_full |
Synthesis and characterization of new amino acyl-4-thiazolidones |
| title_fullStr |
Synthesis and characterization of new amino acyl-4-thiazolidones |
| title_full_unstemmed |
Synthesis and characterization of new amino acyl-4-thiazolidones |
| title_sort |
synthesis and characterization of new amino acyl-4-thiazolidones |
| publisher |
Sociedade Brasileira de Química |
| series |
Química Nova |
| issn |
0100-4042 1678-7064 |
| publishDate |
2007-04-01 |
| description |
A series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazolidone and the alpha-amino acid condensation reactions were carried out using strategies for peptide synthesis. The characterization of this new class of compounds was performed using IR and ¹H-NMR spectroscopy. |
| topic |
4-thiazolidone peptidyl derivatives heterocyclic compounds |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000200008 |
| work_keys_str_mv |
AT anacristinalimaleite synthesisandcharacterizationofnewaminoacyl4thiazolidones AT lucienemariafsantos synthesisandcharacterizationofnewaminoacyl4thiazolidones AT diogorodrigodemmoreira synthesisandcharacterizationofnewaminoacyl4thiazolidones AT dalcijosebrondani synthesisandcharacterizationofnewaminoacyl4thiazolidones |
| _version_ |
1725382726156025856 |