A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis

A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis

Toxic epidermal necrolysis represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Atorvastatin, a blood cholesterol–lowering agent, is a recognized cause of rhabdomyolysis; while naproxen, a widely used nonsteroidal anti-inflammatory drug, is a known cause of phot...

Full description

Bibliographic Details
Main Authors: Sheik Oaleed Noordally, Schoeb Sohawon, Julien Vanderhulst, Ruth Duttmann, Francis Corazza, Jacques Devriendt
Format: Article
Language:English
Published: King Faisal Specialist Hospital and Research Centre 2012-05-01
Series:Annals of Saudi Medicine
Online Access:https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.309
id doaj-6616ff57cf734b13aaa9ef30c085e30f
record_format Article
spelling doaj-6616ff57cf734b13aaa9ef30c085e30f2020-11-24T21:26:37ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662012-05-0132330931110.5144/0256-4947.2012.309asm-3-309A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysisSheik Oaleed Noordally0Schoeb Sohawon1Julien Vanderhulst2Ruth Duttmann3Francis Corazza4Jacques Devriendt5From the Department of Critical Care Medicine, Centre Hospitalier Universitaire, Brugmann, BelgiumFrom the Department of Surgery, Erasme Hospital, Brugmann, BelgiumFrom the Department of Critical Care Medicine, Centre Hospitalier Universitaire, Brugmann, BelgiumFrom the Department of Pathology, Centre Hospitalier Universitaire, Brugmann, BelgiumFrom the Laboratory of Immunology and Haematology, Centre Hospitalier Universitaire Brugmann, Free University of Brussels, Brussels, BelgiumFrom the Department of Critical Care Medicine, Centre Hospitalier Universitaire, Brugmann, BelgiumToxic epidermal necrolysis represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Atorvastatin, a blood cholesterol–lowering agent, is a recognized cause of rhabdomyolysis; while naproxen, a widely used nonsteroidal anti-inflammatory drug, is a known cause of photo-induced skin lesions. We report the first fatal case of drug-induced toxic epidermal necrolysis associated with severe muscle necrosis due to the use of a nonsteroidal anti-inflammatory drug and a statin with very high levels of creatine phosphokinase leading to acute kidney injury, disseminated intravascular coagulation, and complete skin necrosis leading to death.https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.309
collection DOAJ
language English
format Article
sources DOAJ
author Sheik Oaleed Noordally
Schoeb Sohawon
Julien Vanderhulst
Ruth Duttmann
Francis Corazza
Jacques Devriendt
spellingShingle Sheik Oaleed Noordally
Schoeb Sohawon
Julien Vanderhulst
Ruth Duttmann
Francis Corazza
Jacques Devriendt
A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
Annals of Saudi Medicine
author_facet Sheik Oaleed Noordally
Schoeb Sohawon
Julien Vanderhulst
Ruth Duttmann
Francis Corazza
Jacques Devriendt
author_sort Sheik Oaleed Noordally
title A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
title_short A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
title_full A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
title_fullStr A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
title_full_unstemmed A fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
title_sort fatal case of cutaneous adverse drug-induced toxic epidermal necrolysis associated with severe rhabdomyolysis
publisher King Faisal Specialist Hospital and Research Centre
series Annals of Saudi Medicine
issn 0256-4947
0975-4466
publishDate 2012-05-01
description Toxic epidermal necrolysis represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Atorvastatin, a blood cholesterol–lowering agent, is a recognized cause of rhabdomyolysis; while naproxen, a widely used nonsteroidal anti-inflammatory drug, is a known cause of photo-induced skin lesions. We report the first fatal case of drug-induced toxic epidermal necrolysis associated with severe muscle necrosis due to the use of a nonsteroidal anti-inflammatory drug and a statin with very high levels of creatine phosphokinase leading to acute kidney injury, disseminated intravascular coagulation, and complete skin necrosis leading to death.
url https://www.annsaudimed.net/doi/full/10.5144/0256-4947.2012.309
work_keys_str_mv AT sheikoaleednoordally afatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT schoebsohawon afatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT julienvanderhulst afatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT ruthduttmann afatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT franciscorazza afatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT jacquesdevriendt afatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT sheikoaleednoordally fatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT schoebsohawon fatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT julienvanderhulst fatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT ruthduttmann fatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT franciscorazza fatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
AT jacquesdevriendt fatalcaseofcutaneousadversedruginducedtoxicepidermalnecrolysisassociatedwithsevererhabdomyolysis
_version_ 1725978591179571200

Similar Items