First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus

This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral...

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Main Authors: Merav Weil, Galia Rahav, Raz Somech, Tali Stauber, Jacqueline Alfandari, Leah Weiss, Ilana Silberstein, Victoria Indenbaum, Itay Bar Or, Ella Mendelson, Danit Sofer, Lester M. Shulman
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:International Journal of Infectious Diseases
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971219301663
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spelling doaj-6615ca4a64cd4db09f3670850f28fbe62020-11-24T20:42:55ZengElsevierInternational Journal of Infectious Diseases1201-97122019-06-01834043First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirusMerav Weil0Galia Rahav1Raz Somech2Tali Stauber3Jacqueline Alfandari4Leah Weiss5Ilana Silberstein6Victoria Indenbaum7Itay Bar Or8Ella Mendelson9Danit Sofer10Lester M. Shulman11Central Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, Israel; Corresponding author at: Head National Center for Polio and Non-polio Enteroviruses, Central Virology Laboratory, Public Health Services, Israel Ministry of Health, Sheba Medical Center, Tel Hashomer 52621, Israel.Infectious Disease Unit, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Department A and Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Department A and Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, IsraelCentral Virology Laboratory, Public Health Services, Israel Ministry of Health, at Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThis is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world. Keywords: Primary immune deficiency (PID), Type 2 vaccine-derived poliovirus (iVDPV2), Stools, Oropharyngeal mucosa, Contact isolation, Droplet isolationhttp://www.sciencedirect.com/science/article/pii/S1201971219301663
collection DOAJ
language English
format Article
sources DOAJ
author Merav Weil
Galia Rahav
Raz Somech
Tali Stauber
Jacqueline Alfandari
Leah Weiss
Ilana Silberstein
Victoria Indenbaum
Itay Bar Or
Ella Mendelson
Danit Sofer
Lester M. Shulman
spellingShingle Merav Weil
Galia Rahav
Raz Somech
Tali Stauber
Jacqueline Alfandari
Leah Weiss
Ilana Silberstein
Victoria Indenbaum
Itay Bar Or
Ella Mendelson
Danit Sofer
Lester M. Shulman
First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus
International Journal of Infectious Diseases
author_facet Merav Weil
Galia Rahav
Raz Somech
Tali Stauber
Jacqueline Alfandari
Leah Weiss
Ilana Silberstein
Victoria Indenbaum
Itay Bar Or
Ella Mendelson
Danit Sofer
Lester M. Shulman
author_sort Merav Weil
title First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus
title_short First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus
title_full First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus
title_fullStr First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus
title_full_unstemmed First report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (iVDPV2) in a primary immune deficient (PID) patient after eradication of wild type 2 poliovirus
title_sort first report of a persistent oropharyngeal infection of type 2 vaccine-derived poliovirus (ivdpv2) in a primary immune deficient (pid) patient after eradication of wild type 2 poliovirus
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
publishDate 2019-06-01
description This is the first report of persistent oropharyngeal mucosal infection with type 2 poliovirus (iVDPV2) in a primary immune deficient patient (PID) after wild type 2 poliovirus eradication. The iVDPV2 also established persistence in the gut. iVDPV2 at both loci evolved independently. Persistent oral infections present a potential risk for oral-oral as well as fecal-oral poliovirus transmission during transition to a poliovirus 2-free world. Keywords: Primary immune deficiency (PID), Type 2 vaccine-derived poliovirus (iVDPV2), Stools, Oropharyngeal mucosa, Contact isolation, Droplet isolation
url http://www.sciencedirect.com/science/article/pii/S1201971219301663
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