Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

Bone metastases are associated with poor prognosis in patients with breast cancer and limited therapeutic options. Here the authors exploit near-infrared light responsive macrophages for the tumor-selective delivery of oxaliplatin prodrug for chemo-photodynamic therapy of primary and bone metastatic...

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Main Authors: Yanjuan Huang, Zilin Guan, Xiuling Dai, Yifeng Shen, Qin Wei, Lingling Ren, Jingwen Jiang, Zhanghong Xiao, Yali Jiang, Di Liu, Zeqian Huang, Xiaoyu Xu, Yong Luo, Chunshun Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24564-0
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spelling doaj-6612050fe360461b84661984dadfcace2021-07-18T11:43:10ZengNature Publishing GroupNature Communications2041-17232021-07-0112112210.1038/s41467-021-24564-0Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancerYanjuan Huang0Zilin Guan1Xiuling Dai2Yifeng Shen3Qin Wei4Lingling Ren5Jingwen Jiang6Zhanghong Xiao7Yali Jiang8Di Liu9Zeqian Huang10Xiaoyu Xu11Yong Luo12Chunshun Zhao13School of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversitySchool of Pharmaceutical Sciences, Sun Yat-sen UniversityBone metastases are associated with poor prognosis in patients with breast cancer and limited therapeutic options. Here the authors exploit near-infrared light responsive macrophages for the tumor-selective delivery of oxaliplatin prodrug for chemo-photodynamic therapy of primary and bone metastatic breast cancer.https://doi.org/10.1038/s41467-021-24564-0
collection DOAJ
language English
format Article
sources DOAJ
author Yanjuan Huang
Zilin Guan
Xiuling Dai
Yifeng Shen
Qin Wei
Lingling Ren
Jingwen Jiang
Zhanghong Xiao
Yali Jiang
Di Liu
Zeqian Huang
Xiaoyu Xu
Yong Luo
Chunshun Zhao
spellingShingle Yanjuan Huang
Zilin Guan
Xiuling Dai
Yifeng Shen
Qin Wei
Lingling Ren
Jingwen Jiang
Zhanghong Xiao
Yali Jiang
Di Liu
Zeqian Huang
Xiaoyu Xu
Yong Luo
Chunshun Zhao
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
Nature Communications
author_facet Yanjuan Huang
Zilin Guan
Xiuling Dai
Yifeng Shen
Qin Wei
Lingling Ren
Jingwen Jiang
Zhanghong Xiao
Yali Jiang
Di Liu
Zeqian Huang
Xiaoyu Xu
Yong Luo
Chunshun Zhao
author_sort Yanjuan Huang
title Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
title_short Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
title_full Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
title_fullStr Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
title_full_unstemmed Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
title_sort engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Bone metastases are associated with poor prognosis in patients with breast cancer and limited therapeutic options. Here the authors exploit near-infrared light responsive macrophages for the tumor-selective delivery of oxaliplatin prodrug for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
url https://doi.org/10.1038/s41467-021-24564-0
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