A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies.

A novel redox method for rapid production of functional bi-specific antibodies for use in early pilot studies.

We demonstrate here a rapid alternative method for the production of functional bi-specific antibodies using the mild reducing agent 2-mercaptoethanesulfonic acid sodium salt (MESNA). Following reduction of a mixture of two monoclonal antibodies with MESNA to break inter heavy chain bonds, this solu...

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Bibliographic Details
Main Authors: Jennifer Carlring, Evy De Leenheer, Andrew William Heath
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3141073?pdf=render

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