Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering

Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering

The immune system is unique among all biological sub-systems in its usage of DNA-editing enzymes to introduce targeted gene mutations and double-strand DNA breaks to diversify antigen receptor genes and combat viral infections. These processes, initiated by specific DNA-editing enzymes, often result...

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Bibliographic Details
Main Authors: Atefeh Ghorbani, Emma M. Quinlan, Mani Larijani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
DNA-editing enzyme
immune response
cancer
gene mutations
cytidine deaminase
AID/APOBEC and ADAR deaminases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642343/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.642343/full

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